Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 4/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.43 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.43 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.42 |
| ▸ | STK4 | Q13043 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17628385 | 1.00 | PRKDC (0.47) | PRKDCCNR2EGLN1OPRM1OPRD1 | |
| SCHEMBL17628084 | 0.89 | SMPD3 (0.46) | PRKDCCNR2OPRM1OPRD1OPRK1 | |
| SCHEMBL17628086 | 0.89 | SMPD3 (0.46) | PRKDCCNR2OPRM1OPRD1OPRK1 | |
| SCHEMBL17627941 | 0.88 | SMPD3 (0.48) | PRKDCCNR2EGLN1SMPD3HRH4 | |
| SCHEMBL17627942 | 0.88 | SMPD3 (0.48) | PRKDCCNR2EGLN1SMPD3HRH4 | |
| SCHEMBL17628428 | 0.87 | SMPD3 (0.49) | PRKDCCNR2SMPD3HRH4 | |
| SCHEMBL17628426 | 0.87 | SMPD3 (0.49) | PRKDCCNR2SMPD3HRH4 | |
| SCHEMBL17628336 | 0.87 | OPRM1 (0.52) | PRKDCCNR2EGLN1OPRM1OPRD1 | |
| SCHEMBL17628334 | 0.87 | OPRM1 (0.52) | PRKDCCNR2EGLN1OPRM1OPRD1 | |
| SCHEMBL17628393 | 0.85 | HRH4 (0.57) | HRH4HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170152241-A9 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | YUHAN CORPORATION (KR) | 2017-06-01 | — | — | US | disclosed |
| EP-3006439-A1 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | Yuhan Corporation (KR) | 2016-04-13 | — | — | EP | disclosed |
| US-20160090374-A1 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | YUHAN CORP (KR) | 2016-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170152241-A9 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | GPR119, GIPR, P2RY4 | PRKDC 4342/4885CNR2 660/4885EGLN1 4341/4885 |
| US-20160090374-A1 | BICYCLIC DERIVATIVE CONTAINING PYRIMIDINE RING, AND PREPARATION METHOD THEREFOR | GPR119, GIPR, P2RY4 | PRKDC 4342/4885CNR2 660/4885EGLN1 4341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.