Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 7/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28633916 | 0.84 | MAOA (0.46) | NPC1SMN1; SMN2HSD17B10NPSR1MAPT | |
| SCHEMBL3057263 | 0.83 | NR1H4 (0.61) | NPC1SMN1; SMN2HSD17B10NPSR1MAPT | |
| SCHEMBL28636371 | 0.81 | MAOA (0.44) | NPC1SMN1; SMN2HSD17B10NPSR1MAPT | |
| SCHEMBL5836424 | 0.81 | NR1H4 (0.66) | NPC1SMN1; SMN2HSD17B10NPSR1MAPT | |
| SCHEMBL20968280 | 0.80 | S1PR1 (0.48) | NPC1SMN1; SMN2HSD17B10NPSR1MAPT | |
| SCHEMBL28651999 | 0.79 | S1PR1 (0.55) | S1PR1S1PR3S1PR5 | |
| SCHEMBL28651748 | 0.79 | MAOA (0.44) | NPC1SMN1; SMN2HSD17B10NPSR1MAOA | |
| SCHEMBL28638112 | 0.78 | S1PR1 (0.44) | MAOAMAOBS1PR1S1PR3MCHR1 | |
| Hydrochloric Acid SCHEMBL28647727 | 0.78 | S1PR1 (0.43) | MAOAMAOBS1PR1S1PR3MCHR1 | |
| SCHEMBL20968217 | 0.77 | NPC1 (0.49) | NPC1SMN1; SMN2HSD17B10NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10662164-B2 | Non-beta lactam antibiotics | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2020-05-26 | — | — | US | disclosed |
| US-10662164-B2 | Non-beta lactam antibiotics | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2020-05-26 | — | — | US | disclosed |
| US-20190127340-A1 | NON-BETA LACTAM ANTIBIOTICS | UNIVERSITY OF NOTRE DAME DU LAC | 2019-05-02 | — | — | US | disclosed |
| US-20190127340-A1 | NON-BETA LACTAM ANTIBIOTICS | UNIVERSITY OF NOTRE DAME DU LAC | 2019-05-02 | — | — | US | disclosed |
| EP-3197888-A2 | NON-BETA LACTAM ANTIBIOTICS | University of Notre Dame du Lac (US) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016049586-A2 | NON-BETA LACTAM ANTIBIOTICS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2016-03-31 | — | — | WO | disclosed |
| WO-2016049586-A2 | NON-BETA LACTAM ANTIBIOTICS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2016-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10662164-B2 | Non-beta lactam antibiotics | OXA1L, O60361, CUTA | NPC1 2521/4885SMN1; SMN2 3703/4885HSD17B10 667/4885 |
| US-20190127340-A1 | NON-BETA LACTAM ANTIBIOTICS | OXA1L, O60361, CUTA | NPC1 2521/4885SMN1; SMN2 3703/4885HSD17B10 667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.