Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetylcholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 8/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.58 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.58 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.58 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.58 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.58 |
| ▸ | PGR | P06401 | 1/20 | 0.58 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.58 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.58 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.58 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.58 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.58 |
| ▸ | GALR3 | O60755 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetylcholine SCHEMBL17629403 | 0.89 | CHRM1 (0.59) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL17629405 | 0.89 | CHRM1 (0.59) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL563048 | 0.85 | CHRM1 (0.54) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL29441892 | 0.82 | CHRM1 (0.68) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL563047 | 0.81 | CHRM1 (0.56) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL6033512 | 0.80 | CHRM1 (0.52) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL28054287 | 0.80 | CHRM1 (0.83) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Aspartic Acid SCHEMBL6033509 | 0.79 | LMNA (0.41) | SMN1; SMN2GALR3LMNATSHRMAPT | |
| Aspartic Acid SCHEMBL28756875 | 0.78 | CPT2 (0.42) | PGRLMNAADRA1AMAPTALOX15 | |
| Acetylcholine SCHEMBL27723856 | 0.78 | CHRM1 (0.95) | CHRM1CHRM3CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197445-B1 | PROLINE OR PROLINE DERIVATIVES FOR THE TREATMENT OF DEMENTIA | SALAMA ZOSER B (DE) | 2021-04-28 | — | — | EP | disclosed |
| US-10328051-B2 | Proline or proline derivatives for the treatment of dementia | SALAMA ZOSER B (DE) | 2019-06-25 | — | — | US | disclosed |
| US-20170239215-A1 | PROLINE OR PROLINE DERIVATIVES FOR THE TREATMENT OF DEMENTIA | SALAMA ZOSER B (DE) | 2017-08-24 | — | — | US | disclosed |
| EP-3197445-A1 | PROLINE OR PROLINE DERIVATIVES FOR THE TREATMENT OF DEMENTIA | Salama, Zoser B. (DE) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016046162-A1 | PROLINE OR PROLINE DERIVATIVES FOR THE TREATMENT OF DEMENTIA | SALAMA ZOSER B (DE) | 2016-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10328051-B2 | Proline or proline derivatives for the treatment of dementia | PSEN2, PSEN1, PRNP | CHRM3 3266/4885CHRM1 3242/4885CHRM2 2567/4885 |
| US-20170239215-A1 | PROLINE OR PROLINE DERIVATIVES FOR THE TREATMENT OF DEMENTIA | PSEN2, PSEN1, PRNP | CHRM3 3266/4885CHRM1 3242/4885CHRM2 2567/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.