Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acetylcholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 known ✓ | P20309 | 8/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.54 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.54 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.54 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.54 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.54 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.54 |
| ▸ | GALR3 | O60755 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetylcholine SCHEMBL563047 | 0.90 | CHRM1 (0.56) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL28345020 | 0.88 | CHRM1 (0.58) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL17629404 | 0.85 | CHRM1 (0.58) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| SCHEMBL8218840 | 0.82 | ADRA2A (0.50) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL17629405 | 0.81 | CHRM1 (0.59) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL17629403 | 0.81 | CHRM1 (0.59) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| D-Glutamate SCHEMBL8218834 | 0.80 | CYP1A2 (0.46) | CYP2C19LMNAMAPTBLMTSHR | |
| Acetylcholine SCHEMBL29441892 | 0.80 | CHRM1 (0.68) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| Acetylcholine SCHEMBL28054287 | 0.78 | CHRM1 (0.83) | CHRM1CHRM3CHRM2CHRM4CHRM5 | |
| D-Glutamate SCHEMBL2208071 | 0.77 | TSHR (0.50) | CYP2C19LMNAMAPTBLMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070287991-A1 | Devices and methods for detection of markers of axial pain with or without radiculopathy | MEDTRONIC, INC. | 2007-12-13 | — | — | US | claimed |
| US-9675657-B2 | Role of an herbal formulation in the prevention and management of age related neurodegenerative disorders with special reference to senile dementia | SRM UNIVERSITY (IN) | 2017-06-13 | — | — | US | disclosed |
| EP-1634075-B1 | Electronic device for communication with living cells | YISSUM RES DEV CO (IL) | 2015-01-14 | — | — | EP | disclosed |
| WO-2012020423-A1 | ROLE OF AN HERBAL FORMULATION IN THE PREVENTION AND MANAGEMENT OF AGE RELATED NEURODEGENERATIVE DISORDERS WITH SPECIAL REFERENCE TO SENILE DEMENTIA | INTERDISCIPLINARY SCHOOL OF INDIAN SYSTEM OF MEDICINE (IN) | 2012-02-16 | — | — | WO | disclosed |
| US-20120034324-A1 | ROLE OF AN HERBAL FORMULATION IN THE PREVENTION AND MANAGEMENT OF AGE RELATED NEURODEGENERATIVE DISORDERS WITH SPECIAL REFERENCE TO SENILE DEMENTIA | SRM UNIVERSITY (IN) | 2012-02-09 | — | — | US | disclosed |
| US-7795039-B2 | provides a surface-substrate for adherence of cells; comprises a micronail structure protruding from the surface, a region of the micronail having cellular-internalization promoting properties; for research purposes, for photography purposes; provide a good electrical and/or chemical coupling | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2010-09-14 | — | — | US | disclosed |
| US-20070099173-A1 | provides a surface-substrate for adherence of cells; comprises a micronail structure protruding from the surface, a region of the micronail having cellular-internalization promoting properties; for research purposes, for photography purposes; provide a good electrical and/or chemical coupling | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2007-05-03 | — | — | US | disclosed |
| EP-1634075-A1 | ELECTRONIC DEVICE FOR COMMUNICATION WITH LIVING CELLS | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004109282-A1 | ELECTRONIC DEVICE FOR COMMUNICATION WITH LIVING CELLS | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2004-12-16 | — | — | WO | disclosed |