Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 12/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31188474 | 0.85 | KDM4E (0.42) | MEN1RAB9AKMT2AKDM4EFKBP1A | |
| Bromide SCHEMBL5041514 | 0.84 | FKBP1A (0.41) | MEN1RAB9AKMT2AKDM4EFKBP1A | |
| SCHEMBL10944188 | 0.79 | PLA2G7 (0.46) | MEN1KMT2AKDM4ECYP1A2PLA2G7 | |
| SCHEMBL7466378 | 0.76 | SMN1; SMN2 (0.50) | RAB9AKDM4EFKBP1ACYP1A2TNF | |
| SCHEMBL22515664 | 0.75 | DNM1 (0.44) | PLA2G7MAPTMAPK1RECQL | |
| SCHEMBL5795312 | 0.75 | MAPT (0.49) | MEN1KMT2AKDM4EFKBP1ATNF | |
| SCHEMBL17213445 | 0.75 | PLA2G7 (0.47) | RAB9AKDM4EPLA2G7MAPTRECQL | |
| SCHEMBL5162227 | 0.74 | GSK3A (0.64) | RAB9ACYP1A2TNFMAPTMAPK1 | |
| SCHEMBL10747764 | 0.74 | TNF (0.47) | RAB9AKDM4ECYP1A2TNFMAPT | |
| SCHEMBL13204644 | 0.73 | MGLL (0.47) | PLA2G7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1193257-B1 | Compounds for ceramide-mediated signal transduction | UNIV CALIFORNIA (US) | 2005-09-07 | — | — | EP | disclosed |
| EP-0986561-B1 | COMPOUNDS FOR INHIBITION OF CERAMIDE-MEDIATED SIGNAL TRANSDUCTION | UNIV CALIFORNIA (US) | 2005-07-27 | — | — | EP | disclosed |
| EP-1193257-A2 | Compounds for ceramide-mediated signal transduction | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2002-04-03 | — | — | EP | disclosed |
| US-5843943-A | Compounds for inhibition of ceramide-mediated signal transduction | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-12-01 | — | — | US | disclosed |