Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17629651 | 0.91 | PKM (0.39) | KDM4EALDH1A1RAB9ANPC1TSHR | |
| SCHEMBL22838667 | 0.76 | PKM (0.55) | KDM4EALDH1A1RAB9ANPC1TSHR | |
| SCHEMBL17629620 | 0.75 | KDM4E (0.52) | KDM4EALDH1A1RAB9ANPC1TSHR | |
| SCHEMBL17629670 | 0.75 | KDM4E (0.47) | KDM4EALDH1A1RAB9ANPC1TSHR | |
| SCHEMBL17629578 | 0.69 | LMNA (0.68) | KDM4EALDH1A1RAB9ANPC1TSHR | |
| SCHEMBL17629630 | 0.67 | EGLN1 (0.72) | ALDH1A1HPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17629646 | 0.66 | KDM4E (0.49) | KDM4EALDH1A1RAB9ANPC1TSHR | |
| SCHEMBL17629608 | 0.66 | USP2 (0.42) | KDM4EALDH1A1RAB9ANPC1TSHR | |
| SCHEMBL19268247 | 0.64 | PKM (0.43) | KDM4EALDH1A1RAB9ANPC1TSHR | |
| SCHEMBL17629490 | 0.64 | EGLN1 (0.50) | KDM4EALDH1A1RAB9ANPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197455-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | Merck Sharp & Dohme Corp. (US) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016049097-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2016-03-31 | — | — | WO | disclosed |