Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ADH5 | P11766 | 2/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27671178 | 0.83 | LMNA (0.54) | LMNAMAPTCYP3A4CYP19A1ADH5 | |
| SCHEMBL17630098 | 0.82 | CYP3A4 (0.48) | LMNAMAPTCYP3A4CYP19A1CYP2D6 | |
| SCHEMBL8337179 | 0.82 | CYP3A4 (0.50) | LMNAMAPTCYP3A4CYP19A1CYP2D6 | |
| SCHEMBL4674986 | 0.80 | PDE4A (0.46) | LMNAMAPTCYP3A4CYP19A1CYP2D6 | |
| SCHEMBL3490259 | 0.77 | LMNA (0.63) | LMNAMAPTCYP3A4CYP19A1CYP11B1 | |
| SCHEMBL993223 | 0.76 | LMNA (0.58) | LMNAMAPTCYP3A4CYP19A1ADH5 | |
| SCHEMBL12310548 | 0.74 | CYP3A4 (0.59) | LMNAMAPTCYP3A4CYP19A1CYP2D6 | |
| SCHEMBL1449607 | 0.73 | LMNA (0.58) | LMNAMAPTCYP3A4CYP19A1CYP2D6 | |
| SCHEMBL6259515 | 0.73 | LMNA (0.58) | LMNAMAPTCYP3A4CYP19A1ADH5 | |
| SCHEMBL14259451 | 0.73 | LMNA (0.58) | LMNAMAPTCYP3A4CYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016046782-A1 | IMIDAZOLE BIARYL COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2016-03-31 | — | — | WO | disclosed |