Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17629975 | 0.80 | LMNA (0.50) | CYP3A4BAZ2BMAPTMEN1KMT2A | |
| SCHEMBL5800531 | 0.79 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL18019402 | 0.78 | ADH5 (0.39) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL12316383 | 0.78 | MKNK1 (0.51) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL17630098 | 0.77 | CYP3A4 (0.48) | CYP3A4BAZ2BMAPTMEN1KMT2A | |
| SCHEMBL31069770 | 0.77 | ADH5 (0.49) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL8337179 | 0.76 | CYP3A4 (0.50) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL12316382 | 0.76 | CYP11B1 (0.51) | CYP3A4BAZ2BMAPTKDM4EMEN1 | |
| SCHEMBL8425351 | 0.75 | MAPT (0.51) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL1785529 | 0.74 | IDO1 (0.53) | CYP3A4BAZ2BMAPTMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885697-A2 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS AND METHODS OF USING SAME | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006121719-A2 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS AND METHODS OF USING SAME | BOEHRINGER INGELHEIM INTERNATIONAL, GMBH (DE) | 2006-11-16 | — | — | WO | disclosed |