Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.40 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.39 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17631604 | 1.00 | DYRK1B (0.44) | DYRK1BUSP30CHEK1UCHL1CDK2AP1 | |
| SCHEMBL17632036 | 0.91 | USP30 (0.50) | USP30CHEK1UCHL1MKNK1 | |
| SCHEMBL17632047 | 0.90 | USP30 (0.41) | DYRK1BUSP30CHEK1UCHL1CDK2AP1 | |
| SCHEMBL17632442 | 0.87 | CHEK1 (0.44) | USP30CHEK1UCHL1GSK3B | |
| SCHEMBL17632150 | 0.87 | USP30 (0.43) | USP30CHEK1UCHL1CDK2AP1 | |
| SCHEMBL17631430 | 0.87 | USP30 (0.38) | DYRK1BUSP30CHEK1UCHL1DYRK1A | |
| SCHEMBL17632265 | 0.86 | USP30 (0.42) | USP30CHEK1UCHL1 | |
| SCHEMBL17632503 | 0.86 | USP30 (0.42) | USP30CHEK1UCHL1CDK2AP1DYRK1A | |
| SCHEMBL17631780 | 0.86 | USP30 (0.39) | USP30UCHL1HSD17B10ALDH1A1 | |
| SCHEMBL17632487 | 0.86 | USP30 (0.41) | USP30CHEK1UCHL1CDK2AP1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197883-A1 | NOVEL COMPOUNDS | Mission Therapeutics Limited (GB) | 2017-08-02 | — | — | EP | claimed |
| WO-2016046530-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2016-03-31 | — | — | WO | claimed |
| EP-3197883-A1 | NOVEL COMPOUNDS | Mission Therapeutics Limited (GB) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016046530-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2016-03-31 | — | — | WO | disclosed |