Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 6/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.40 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.38 |
| ▸ | MELK | Q14680 | 3/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | GAK | O14976 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | FES | P07332 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17632016 | 0.91 | USP30 (0.40) | USP30CHEK1UCHL1CDK2AP1ABL1 | |
| SCHEMBL17632036 | 0.91 | USP30 (0.50) | USP30CHEK1KCNH2UCHL1 | |
| SCHEMBL17632150 | 0.89 | USP30 (0.43) | USP30CHEK1UCHL1CDK2AP1 | |
| SCHEMBL17632442 | 0.89 | CHEK1 (0.44) | USP30CHEK1UCHL1 | |
| SCHEMBL17632265 | 0.89 | USP30 (0.42) | USP30CHEK1KCNH2UCHL1AAK1 | |
| SCHEMBL17631539 | 0.88 | USP30 (0.42) | USP30CHEK1UCHL1DYRK1A | |
| SCHEMBL17632483 | 0.88 | USP30 (0.42) | USP30CHEK1KCNH2UCHL1FYN | |
| SCHEMBL17631680 | 0.87 | CHEK1 (0.40) | USP30CHEK1UCHL1DYRK1AAKT1 | |
| SCHEMBL17632415 | 0.86 | CHEK1 (0.41) | USP30CHEK1KCNH2UCHL1CDK2AP1 | |
| SCHEMBL17631604 | 0.86 | DYRK1B (0.44) | USP30CHEK1UCHL1CDK2AP1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197883-A1 | NOVEL COMPOUNDS | Mission Therapeutics Limited (GB) | 2017-08-02 | — | — | EP | claimed |
| WO-2016046530-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2016-03-31 | — | — | WO | claimed |