Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 5/20 | 0.36 |
| ▸ | CDK7 | P50613 | 3/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.36 |
| ▸ | CCNH | P51946 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 5/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.35 |
| ▸ | CIT | O14578 | 1/20 | 0.35 |
| ▸ | CASK | O14936 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | GAK | O14976 | 1/20 | 0.35 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.35 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.35 |
| ▸ | ULK1 | O75385 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.35 |
| ▸ | PAK3 | O75914 | 1/20 | 0.35 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | CDK14 | O94921 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17631689 | 0.85 | SMN1; SMN2 (0.35) | CDK9USP30REN | |
| SCHEMBL17632104 | 0.78 | SLC6A2 (0.33) | CDK9 | |
| SCHEMBL17632036 | 0.78 | USP30 (0.50) | MKNK1USP30 | |
| SCHEMBL17632487 | 0.78 | USP30 (0.41) | GSK3BDYRK1AUSP30 | |
| SCHEMBL17632491 | 0.78 | CHEK1 (0.42) | GSK3BDYRK1AUSP30 | |
| SCHEMBL17631612 | 0.78 | — | — | |
| SCHEMBL17632047 | 0.78 | USP30 (0.41) | BRAFGSK3BDYRK1ADYRK1BUSP30 | |
| SCHEMBL17632442 | 0.77 | CHEK1 (0.44) | GSK3BUSP30 | |
| SCHEMBL17631680 | 0.77 | CHEK1 (0.40) | GSK3BDYRK1AUSP30 | |
| SCHEMBL17632937 | 0.77 | CHEK1 (0.37) | CDK9USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197883-A1 | NOVEL COMPOUNDS | Mission Therapeutics Limited (GB) | 2017-08-02 | — | — | EP | claimed |
| WO-2016046530-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2016-03-31 | — | — | WO | claimed |
| EP-3197883-A1 | NOVEL COMPOUNDS | Mission Therapeutics Limited (GB) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016046530-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2016-03-31 | — | — | WO | disclosed |