Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.38 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CTSC | P53634 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17632016 | 0.89 | USP30 (0.40) | CHEK1USP30CDK2AP1UCHL1KDM1A | |
| SCHEMBL17632047 | 0.88 | USP30 (0.41) | CHEK1USP30CDK2AP1UCHL1KDM1A | |
| SCHEMBL17632487 | 0.88 | USP30 (0.41) | CHEK1USP30CDK2AP1KCNH2UCHL1 | |
| SCHEMBL17632491 | 0.88 | CHEK1 (0.42) | CHEK1USP30CDK2AP1UCHL1SLC6A4 | |
| SCHEMBL17631680 | 0.87 | CHEK1 (0.40) | CHEK1USP30UCHL1KDM1AWNT1 | |
| SCHEMBL17631830 | 0.87 | USP30 (0.40) | CHEK1USP30CDK2AP1UCHL1WNT1 | |
| SCHEMBL17632036 | 0.87 | USP30 (0.50) | CHEK1USP30KCNH2UCHL1 | |
| SCHEMBL17632503 | 0.86 | USP30 (0.42) | CHEK1USP30CDK2AP1KCNH2UCHL1 | |
| SCHEMBL17632604 | 0.86 | UCHL1 (0.43) | CHEK1USP30CDK2AP1UCHL1KDM1A | |
| SCHEMBL17632442 | 0.85 | CHEK1 (0.44) | CHEK1USP30UCHL1SLC6A4GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197883-A1 | NOVEL COMPOUNDS | Mission Therapeutics Limited (GB) | 2017-08-02 | — | — | EP | claimed |
| WO-2016046530-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2016-03-31 | — | — | WO | claimed |
| EP-3197883-A1 | NOVEL COMPOUNDS | Mission Therapeutics Limited (GB) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016046530-A1 | NOVEL COMPOUNDS | MISSION THERAPEUTICS LTD (GB) | 2016-03-31 | — | — | WO | disclosed |