Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 15/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 8/20 | 0.34 |
| ▸ | EGLN3 | Q9H6Z9 | 8/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17633173 | 0.79 | EGLN1 (0.36) | EGLN1EGLN2EGLN3 | |
| SCHEMBL17633307 | 0.77 | EGLN1 (0.36) | EGLN1EGLN2EGLN3 | |
| SCHEMBL17633124 | 0.76 | EGLN1 (0.41) | EGLN1EGLN2EGLN3 | |
| SCHEMBL17629490 | 0.71 | EGLN1 (0.50) | EGLN1EGLN2EGLN3 | |
| SCHEMBL17629528 | 0.69 | EGLN1 (0.38) | P2RX7EGLN1EGLN2EGLN3 | |
| SCHEMBL17633111 | 0.64 | EGLN1 (0.62) | EGLN1EGLN2EGLN3 | |
| SCHEMBL17629646 | 0.64 | KDM4E (0.49) | EGLN1EGLN2EGLN3 | |
| SCHEMBL17629620 | 0.62 | KDM4E (0.52) | EGLN1EGLN2EGLN3 | |
| SCHEMBL19227012 | 0.60 | PKM (0.41) | EGLN1 | |
| SCHEMBL17629417 | 0.60 | PKM (0.43) | EGLN1EGLN2EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197451-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | Merck Sharp & Dohme Corp. (US) | 2017-08-02 | — | — | EP | claimed |
| WO-2016049100-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2016-03-31 | — | — | WO | claimed |
| EP-3197451-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | Merck Sharp & Dohme Corp. (US) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016049100-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2016-03-31 | — | — | WO | disclosed |