Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 13/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 4/20 | 0.34 |
| ▸ | EGLN3 | Q9H6Z9 | 4/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | SLC8A1 | P32418 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17629528 | 0.93 | EGLN1 (0.38) | EGLN1KCNK3EGLN2EGLN3CD274 | |
| SCHEMBL17633307 | 0.77 | EGLN1 (0.36) | EGLN1EGLN2EGLN3 | |
| SCHEMBL17633173 | 0.77 | EGLN1 (0.36) | EGLN1EGLN2EGLN3 | |
| SCHEMBL17633112 | 0.76 | P2RX7 (0.37) | EGLN1EGLN2EGLN3 | |
| SCHEMBL17629490 | 0.69 | EGLN1 (0.50) | EGLN1EGLN2EGLN3 | |
| SCHEMBL17633120 | 0.66 | EGLN1 (0.73) | EGLN1EGLN2EGLN3 | |
| SCHEMBL17629526 | 0.63 | EGLN1 (0.74) | EGLN1EGLN2EGLN3 | |
| SCHEMBL17629646 | 0.62 | KDM4E (0.49) | EGLN1EGLN2EGLN3 | |
| SCHEMBL18228247 | 0.62 | NNMT (0.47) | CHRNA7 | |
| SCHEMBL17629620 | 0.60 | KDM4E (0.52) | EGLN1EGLN2EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3197451-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | Merck Sharp & Dohme Corp. (US) | 2017-08-02 | — | — | EP | claimed |
| WO-2016049100-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2016-03-31 | — | — | WO | claimed |
| EP-3197451-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | Merck Sharp & Dohme Corp. (US) | 2017-08-02 | — | — | EP | disclosed |
| WO-2016049100-A1 | INHIBITORS OF HIF PROLYL HYDROXYLASE | MERCK SHARP & DOHME CORP. (US) | 2016-03-31 | — | — | WO | disclosed |