Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16122661 | 0.90 | ALDH1A1 (0.45) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL16122825 | 0.89 | ALDH1A1 (0.44) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL16122580 | 0.89 | ALDH1A1 (0.44) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL16121830 | 0.87 | ALDH1A1 (0.42) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL16094150 | 0.84 | KRAS (0.40) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL16122832 | 0.84 | L3MBTL1 (0.46) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL25930508 | 0.83 | L3MBTL1 (0.48) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL24460021 | 0.83 | ALDH1A1 (0.56) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL16122493 | 0.82 | L3MBTL1 (0.47) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL16122828 | 0.82 | HTT (0.50) | ALDH1A1KDM4EMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016049565-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF RAS | ARAXES PHARMA LLC (US) | 2016-03-31 | — | — | WO | disclosed |
| WO-2016049565-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF RAS | ARAXES PHARMA LLC (US) | 2016-03-31 | — | — | WO | disclosed |