Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 6/20 | 0.43 |
| ▸ | GRM5 | P41594 | 5/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | LIPC | P11150 | 1/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3221067 | 0.88 | MAPT (0.37) | PDK4SCN9AHTR6 | |
| SCHEMBL24718042 | 0.86 | PDK4 (0.48) | PDK4SCN9AHTR6JAK1GRM1 | |
| SCHEMBL30798488 | 0.86 | PDK4 (0.48) | PDK4SCN9AHTR6JAK1GRM1 | |
| SCHEMBL1764181 | 0.85 | PDK4 (0.53) | PDK4SCN9AHTR6JAK1GRM1 | |
| SCHEMBL1763593 | 0.84 | PDK4 (0.47) | PDK4SCN9AHTR6JAK1GRM1 | |
| SCHEMBL3033965 | 0.79 | NAMPT (0.54) | PDK4SCN9AJAK1GRM1GRM5 | |
| SCHEMBL31700764 | 0.79 | PDK4 (0.53) | PDK4SCN9AHTR6JAK1GRM1 | |
| SCHEMBL8075949 | 0.78 | PDK4 (0.64) | PDK4SCN9AHTR6JAK1GRM1 | |
| SCHEMBL30736543 | 0.78 | PDK4 (0.64) | PDK4SCN9AHTR6JAK1GRM1 | |
| SCHEMBL31167740 | 0.78 | JAK1 (0.49) | PDK4SCN9AJAK1GRM1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118262-A1 | Pyrrolidinyl and Piperidinyl Compounds Useful as NHE-1 Inhibitiors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118262-A1 | Pyrrolidinyl and Piperidinyl Compounds Useful as NHE-1 Inhibitiors | NHERF1, SLC9A1, SLC9A5 | PDK4 717/4885SCN9A 192/4885HTR6 1324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.