Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 10/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17643349 | 0.85 | ALDH1A1 (0.47) | BLMALOX15TSHRKMT2AMEN1 | |
| SCHEMBL16101856 | 0.82 | HSP90AA1 (0.48) | HSP90AA1LMNATP53ALOX15TSHR | |
| SCHEMBL16100490 | 0.79 | MAPT (0.42) | HSP90AA1LMNATP53ALOX15TSHR | |
| SCHEMBL16100491 | 0.79 | MAPT (0.42) | HSP90AA1LMNATP53ALOX15TSHR | |
| SCHEMBL16117911 | 0.77 | HSP90AA1 (0.51) | HSP90AA1RAB9A | |
| SCHEMBL16099343 | 0.71 | ALDH1A1 (0.50) | ALOX15TSHRKMT2AMEN1ALDH1A1 | |
| SCHEMBL26764213 | 0.71 | ALDH1A1 (0.62) | HSP90AA1LMNATP53ALOX15TSHR | |
| SCHEMBL20259855 | 0.71 | KRAS (0.50) | BLMTSHRALDH1A1EPHX2 | |
| SCHEMBL16117894 | 0.71 | LMNA (0.51) | HSP90AA1LMNATP53ALOX15TSHR | |
| SCHEMBL16117904 | 0.70 | HSP90AA1 (0.51) | HSP90AA1LMNATP53ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016049565-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF RAS | ARAXES PHARMA LLC (US) | 2016-03-31 | — | — | WO | disclosed |