Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 5/20 | 0.32 |
| ▸ | MAOA | P21397 | 4/20 | 0.32 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16266151 | 0.69 | OPRM1 (0.36) | OPRM1OPRK1OPRL1ALDH1A1MAOB | |
| SCHEMBL2969527 | 0.65 | OPRM1 (0.44) | OPRM1OPRK1OPRL1MAOBMAOA | |
| SCHEMBL11453348 | 0.65 | ALDH1A1 (0.40) | OPRM1OPRK1OPRL1LMNATSHR | |
| SCHEMBL15327787 | 0.65 | MEN1 (0.35) | OPRM1OPRK1OPRL1TSHRMAOB | |
| SCHEMBL10876622 | 0.63 | OPRM1 (0.41) | OPRM1OPRK1OPRL1LMNAALDH1A1 | |
| SCHEMBL5480380 | 0.63 | OPRM1 (0.41) | OPRM1OPRK1OPRL1ALDH1A1MAOB | |
| SCHEMBL5076533 | 0.63 | MEN1 (0.39) | OPRM1OPRK1OPRL1MAOBMAOA | |
| SCHEMBL968174 | 0.61 | HDAC4 (0.42) | OPRM1OPRK1OPRL1MAOBMAOA | |
| SCHEMBL15954140 | 0.61 | DPP4 (0.41) | OPRM1OPRK1OPRL1MAOBMAOA | |
| SCHEMBL5274478 | 0.61 | ALDH1A1 (0.31) | OPRM1OPRK1OPRL1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782903-B1 | NOVEL PYRROLIDINE DERIVATIVES AS INHIBITORS OF CATHEPSIN | HOFFMANN LA ROCHE (CH) | 2016-04-06 | — | — | EP | claimed |