Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ABL1 | P00519 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 5/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.40 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2787427 | 0.88 | STIM1 (0.48) | MAPTABL1POLBTP53SMN1; SMN2 | |
| SCHEMBL1828387 | 0.84 | LMNA (0.52) | MAPTABL1POLBTP53SMN1; SMN2 | |
| SCHEMBL16456511 | 0.81 | IMPDH2 (0.44) | — | |
| SCHEMBL2785171 | 0.72 | CYP3A4 (0.41) | MAPTPOLBTP53SMN1; SMN2AURKB | |
| SCHEMBL1827209 | 0.72 | ORAI1 (0.56) | MAPTABL1POLBSMN1; SMN2NPC1 | |
| SCHEMBL16456528 | 0.71 | ABL1 (0.42) | ABL1 | |
| SCHEMBL16456595 | 0.71 | MAPK14 (0.37) | MAPTPOLBCYP3A4MEN1KMT2A | |
| SCHEMBL17644785 | 0.69 | IL2 (0.46) | MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL16363177 | 0.69 | LMNA (0.52) | MAPTPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL2784228 | 0.69 | KDM4E (0.42) | MAPTPOLBSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651232-B1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2010-12-22 | — | — | EP | claimed |