⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL293669 | 0.80 | — | — | |
| SCHEMBL1780286 | 0.78 | — | — | |
| SCHEMBL984869 | 0.78 | — | — | |
| SCHEMBL10049904 | 0.78 | — | — | |
| SCHEMBL1061779 | 0.75 | HTR2A (0.40) | — | |
| SCHEMBL13242164 | 0.75 | THRB (0.40) | — | |
| SCHEMBL11172952 | 0.75 | DRD2 (0.35) | — | |
| SCHEMBL255119 | 0.75 | — | — | |
| SCHEMBL23985340 | 0.74 | DRD2 (0.39) | — | |
| SCHEMBL24884612 | 0.74 | THRB (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3095781-B1 | INDOLE COMPOUND | ASTELLAS PHARMA INC (JP) | 2018-10-03 | — | — | EP | disclosed |
| US-9637451-B2 | Indole compound | ASTELLAS PHARMA INC. (JP) | 2017-05-02 | — | — | US | disclosed |
| EP-3095781-A1 | INDOLE COMPOUND | Astellas Pharma Inc. (JP) | 2016-11-23 | — | — | EP | disclosed |
| US-20160332966-A1 | INDOLE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2016-11-17 | — | — | US | disclosed |
| US-9403789-B2 | Benzofuran-containing amino acid inhibitors of cytochrome P450 | SEQUOIA PHARMACEUTICALS, INC. (US) | 2016-08-02 | — | — | US | disclosed |
| US-9403789-B2 | Benzofuran-containing amino acid inhibitors of cytochrome P450 | SEQUOIA PHARMACEUTICALS, INC. (US) | 2016-08-02 | — | — | US | disclosed |
| US-9403789-B2 | Benzofuran-containing amino acid inhibitors of cytochrome P450 | SEQUOIA PHARMACEUTICALS, INC. (US) | 2016-08-02 | — | — | US | disclosed |
| US-20110124578-A1 | AMINO ACID INHIBITORS OF CYTOCHROME P450 | SEQUOIA PHARMACEUTICALS INC. (US) | 2011-05-26 | — | — | US | disclosed |
| US-20110124578-A1 | AMINO ACID INHIBITORS OF CYTOCHROME P450 | SEQUOIA PHARMACEUTICALS INC. (US) | 2011-05-26 | — | — | US | disclosed |
| WO-2009105774-A2 | AMINO ACID INHIBITORS OF CYTOCHROME P450 | SEQUOIA PHARMACEUTICALS, INC. (US) | 2009-08-27 | — | — | WO | disclosed |
| US-RE34201-E | Analgesics | ANAQUEST, INC. (US) | 1993-03-23 | — | — | US | disclosed |
| US-5053411-A | Analgesics | ANAQUEST, INC. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0396282-A2 | N-aryl-N-[4-(heterocyclicalkyl) piperidinyl]amides and pharmaceutical compositions and methods employing such compounds | BOC, INC. (US) | 1990-11-07 | — | — | EP | disclosed |