Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | NAALAD2 | Q9Y3Q0 | 3/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.39 |
| ▸ | ENPEP | Q07075 | 2/20 | 0.39 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propionic Acid SCHEMBL27738326 | 1.00 | FFAR3 (0.42) | FFAR3CYP1A2NAALAD2FOLH1ENPEP | |
| SCHEMBL4751297 | 0.91 | NAALAD2 (0.45) | CYP1A2NAALAD2FOLH1ENPEPOR51E2 | |
| Ammonia Solution, Strong SCHEMBL7895146 | 0.89 | NAALAD2 (0.43) | CYP1A2NAALAD2FOLH1ENPEPOR51E2 | |
| Ethylene Glycol SCHEMBL15645227 | 0.87 | NAALAD2 (0.42) | CYP1A2NAALAD2FOLH1ENPEPOR51E2 | |
| Isobutanol SCHEMBL31333080 | 0.81 | FFAR3 (0.43) | FFAR3CYP1A2NAALAD2FOLH1ENPEP | |
| Glycerin SCHEMBL30749460 | 0.79 | FFAR3 (0.59) | FFAR3OR51E2GABRR1FFAR4FFAR1 | |
| Glycerin SCHEMBL8830214 | 0.79 | FFAR3 (0.59) | FFAR3OR51E2GABRR1FFAR4FFAR1 | |
| Glycerin SCHEMBL274755 | 0.79 | FFAR3 (0.59) | FFAR3OR51E2GABRR1FFAR4FFAR1 | |
| Glycerin SCHEMBL78123 | 0.79 | FFAR3 (0.59) | FFAR3OR51E2GABRR1FFAR4FFAR1 | |
| Glycerin SCHEMBL30494639 | 0.79 | FFAR3 (0.59) | FFAR3OR51E2GABRR1FFAR4FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204358-B1 | CO-CRYSTALS OF MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMA (US) | 2018-09-19 | — | — | EP | disclosed |
| EP-3204358-A1 | CO-CRYSTALS OF MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2017-08-16 | — | — | EP | disclosed |
| US-9701639-B2 | Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2017-07-11 | — | — | US | disclosed |
| WO-2016057730-A1 | CO-CRYSTALS OF MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | STROHMEIER MARK (US) | 2016-04-14 | — | — | WO | disclosed |
| US-20160096807-A1 | CO-CRYSTALS OF MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160096807-A1 | CO-CRYSTALS OF MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | CFTR, CLIC1, CLIC4 | FFAR3 507/4885CYP1A2 4729/4885NAALAD2 2837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.