Sugi Predict

Sugi Predict / Compounds / SCHEMBL17646246

SCHEMBL17646246

SCHEMBL17646246

N[C@@H](CCCCNC(=O)OCc1ccccc1)C(=O)c1nc2ccccc2s1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ANPEP P15144 1/20 0.55
▸ DPP8 Q6V1X1 3/20 0.54
▸ DPP7 Q9UHL4 3/20 0.54
▸ DPP4 P27487 2/20 0.53
▸ DPP9 Q86TI2 2/20 0.53
▸ HDAC3 O15379 1/20 0.53
▸ HDAC4 P56524 1/20 0.53
▸ HDAC1 Q13547 1/20 0.53
▸ HDAC7 Q8WUI4 1/20 0.53
▸ HDAC2 Q92769 1/20 0.53
▸ HDAC10 Q969S8 1/20 0.53
▸ HDAC11 Q96DB2 1/20 0.53
▸ HDAC8 Q9BY41 1/20 0.53
▸ HDAC6 Q9UBN7 1/20 0.53
▸ HDAC9 Q9UKV0 1/20 0.53
▸ HDAC5 Q9UQL6 1/20 0.53
▸ SLC1A3 P43003 1/20 0.47
▸ SLC1A1 P43005 1/20 0.47
▸ L3MBTL1 Q9Y468 1/20 0.47
▸ HTT P42858 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17672361 1.00 ANPEP (0.55) ANPEPDPP8DPP7DPP4DPP9
Hydrochloric Acid SCHEMBL17646327 0.99 ANPEP (0.54) ANPEPDPP8DPP7DPP4DPP9
Hydrochloric Acid SCHEMBL21489552 0.99 ANPEP (0.54) ANPEPDPP8DPP7DPP4DPP9
SCHEMBL17661731 0.88 HDAC3 (0.51) ANPEPHDAC3HDAC4HDAC1HDAC7
SCHEMBL17665927 0.87 HDAC3 (0.54) DPP8DPP7HDAC3HDAC4HDAC1
SCHEMBL17672358 0.86 HDAC3 (0.53) DPP8DPP7DPP4DPP9HDAC3
SCHEMBL22150087 0.85 CA1 (0.56) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL17646299 0.85 CA1 (0.56) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL17646294 0.83 MAPT (0.58) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL17646310 0.83 MAPT (0.58) HDAC3HDAC4HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11332464-B2 Inhibitors of lysine gingipain Cortexyme, Inc. (US) 2022-05-17 — — US disclosed
US-20210017167-A1 INHIBITORS OF LYSINE GINGIPAIN Cortexyme, Inc. (US) 2021-01-21 — — US disclosed
EP-3204352-B1 INHIBITORS OF LYSINE GINGIPAIN CORTEXYME INC (US) 2020-07-01 — — EP disclosed
CN-111349053-A Inhibitors of lysine porphyromonas gingivalis protease 库特克希米公司 2020-06-30 — — CN disclosed
US-10676470-B2 Inhibitors of lysine gingipain Cortexyme, Inc. (US) 2020-06-09 — — US disclosed
CN-107108468-B Inhibitors of lysine porphyromonas gingivalis protease 库特克希米公司 2020-01-03 — — CN disclosed
US-20190322659-A1 INHIBITORS OF LYSINE GINGIPAIN Cortexyme, Inc. (US) 2019-10-24 — — US disclosed
US-10301301-B2 Inhibitors of lysine gingipain Cortexyme, Inc. (US) 2019-05-28 — — US disclosed
US-20180346460-A1 INHIBITORS OF LYSINE GINGIPAIN Cortexyme, Inc. (US) 2018-12-06 — — US disclosed
US-9988375-B2 Inhibitors of lysine gingipain Cortexyme, Inc. (US) 2018-06-05 — — US disclosed
US-9988375-B2 Inhibitors of lysine gingipain Cortexyme, Inc. (US) 2018-06-05 — — US disclosed
US-20170349537-A1 INHIBITORS OF LYSINE GINGIPAIN Cortexyme, Inc. (US) 2017-12-07 — — US disclosed
US-20170349537-A1 INHIBITORS OF LYSINE GINGIPAIN Cortexyme, Inc. (US) 2017-12-07 — — US disclosed
US-20170349537-A1 INHIBITORS OF LYSINE GINGIPAIN Cortexyme, Inc. (US) 2017-12-07 — — US disclosed
US-9758473-B2 Inhibitors of lysine gingipain Cortexyme, Inc. (US) 2017-09-12 — — US disclosed
US-9758473-B2 Inhibitors of lysine gingipain Cortexyme, Inc. (US) 2017-09-12 — — US disclosed
EP-3204352-A2 INHIBITORS OF LYSINE GINGIPAIN Cortexyme, Inc. (US) 2017-08-16 — — EP disclosed
WO-2016057413-A2 INHIBITORS OF LYSINE GINGIPAIN Cortexyme, Inc. (US) 2016-04-14 — — WO disclosed
US-20160096830-A1 INHIBITORS OF LYSINE GINGIPAIN Cortexyme, Inc. (US) 2016-04-07 — — US disclosed
US-20160096830-A1 INHIBITORS OF LYSINE GINGIPAIN Cortexyme, Inc. (US) 2016-04-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180346460-A1 INHIBITORS OF LYSINE GINGIPAIN ENPEP, PHYKPL, PREP ANPEP 21/4885DPP8 738/4885DPP7 441/4885
US-20190322659-A1 INHIBITORS OF LYSINE GINGIPAIN ENPEP, PHYKPL, PREP ANPEP 21/4885DPP8 738/4885DPP7 441/4885
US-20210017167-A1 INHIBITORS OF LYSINE GINGIPAIN ENPEP, PHYKPL, PREP ANPEP 21/4885DPP8 738/4885DPP7 441/4885
US-10676470-B2 Inhibitors of lysine gingipain ENPEP, PHYKPL, PREP ANPEP 21/4885DPP8 738/4885DPP7 441/4885
US-20170349537-A1 INHIBITORS OF LYSINE GINGIPAIN ENPEP, PHYKPL, PREP ANPEP 21/4885DPP8 738/4885DPP7 441/4885
US-20160096830-A1 INHIBITORS OF LYSINE GINGIPAIN ENPEP, PHYKPL, PREP ANPEP 21/4885DPP8 738/4885DPP7 441/4885
US-11332464-B2 Inhibitors of lysine gingipain ENPEP, PHYKPL, PREP ANPEP 21/4885DPP8 738/4885DPP7 441/4885
US-10301301-B2 Inhibitors of lysine gingipain ENPEP, PHYKPL, PREP ANPEP 21/4885DPP8 738/4885DPP7 441/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.