Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | GCG | P01275 | 8/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PTGFR | P43088 | 3/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17653169 | 0.83 | ABL1 (0.35) | P2RX7AAK1GCGMEN1KMT2A | |
| SCHEMBL17653291 | 0.70 | AAK1 (0.42) | AAK1SMN1; SMN2PTGFRCYP2D6CYP2C19 | |
| SCHEMBL17653109 | 0.65 | AAK1 (0.64) | AAK1 | |
| SCHEMBL888951 | 0.62 | NPC1 (0.41) | AAK1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL22672456 | 0.60 | TDP1 (0.46) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16465343 | 0.60 | P2RX7 (0.75) | P2RX7GCGKMT2ASMN1; SMN2 | |
| SCHEMBL27938398 | 0.59 | UGT2B7 (0.48) | MEN1KMT2ACYP2D6 | |
| Hydrochloric Acid SCHEMBL27743035 | 0.59 | KMT2A (0.46) | GCGMEN1KMT2ASMN1; SMN2CYP2C19 | |
| SCHEMBL29535015 | 0.58 | LCK (0.33) | — | |
| SCHEMBL10365027 | 0.58 | CYP2A6 (0.49) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3200797-A1 | QUINAZOLINE-BASED KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-08-09 | — | — | EP | disclosed |
| WO-2016053794-A1 | QUINAZOLINE-BASED KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-04-07 | — | — | WO | disclosed |