Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | CCR4 | P51679 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17653415 | 0.75 | AAK1 (0.40) | AAK1HRH4CCR4 | |
| SCHEMBL17653165 | 0.69 | AAK1 (0.43) | AAK1 | |
| SCHEMBL17653201 | 0.68 | AAK1 (0.40) | AAK1HRH4CCR4 | |
| SCHEMBL25959324 | 0.66 | ELANE (0.33) | ELANE | |
| SCHEMBL17653273 | 0.64 | CCR4 (0.42) | AAK1CCR4 | |
| SCHEMBL17653357 | 0.63 | KCNH2 (0.42) | AAK1 | |
| SCHEMBL25523664 | 0.63 | TRIM58 (0.34) | — | |
| SCHEMBL4263679 | 0.62 | SLC6A2 (0.38) | — | |
| SCHEMBL17653149 | 0.60 | AAK1 (0.43) | AAK1 | |
| SCHEMBL17653224 | 0.60 | AAK1 (0.40) | AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3200797-A1 | QUINAZOLINE-BASED KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-08-09 | — | — | EP | disclosed |
| WO-2016053794-A1 | QUINAZOLINE-BASED KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-04-07 | — | — | WO | disclosed |