Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 3/20 | 0.42 |
| ▸ | ACHE | P22303 | 8/20 | 0.40 |
| ▸ | ACP1 | P24666 | 2/20 | 0.39 |
| ▸ | APP | P05067 | 6/20 | 0.39 |
| ▸ | BCHE | P06276 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17653119 | 0.69 | ADORA3 (0.49) | SMN1; SMN2AAK1 | |
| SCHEMBL17653165 | 0.65 | AAK1 (0.43) | KDM4EALDH1A1GAAMAPTL3MBTL1 | |
| SCHEMBL17653274 | 0.64 | AAK1 (0.33) | CCR4AAK1 | |
| SCHEMBL4093298 | 0.63 | APP (0.65) | CCR4ACHEACP1APPBCHE | |
| SCHEMBL4095030 | 0.63 | APP (0.60) | CCR4ACHEACP1APPBCHE | |
| SCHEMBL16695847 | 0.62 | CCR4 (0.47) | CCR4ACP1APPKDM4EALDH1A1 | |
| SCHEMBL17653201 | 0.62 | AAK1 (0.40) | CCR4KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL31649377 | 0.61 | KDM4E (0.56) | ACHEBCHEKDM4EALDH1A1MAPT | |
| SCHEMBL4631122 | 0.61 | ALDH1A1 (0.44) | ACHEBCHEKDM4EALDH1A1GAA | |
| SCHEMBL4860036 | 0.60 | ACP1 (0.74) | ACP1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3200797-A1 | QUINAZOLINE-BASED KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-08-09 | — | — | EP | disclosed |
| WO-2016053794-A1 | QUINAZOLINE-BASED KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-04-07 | — | — | WO | disclosed |