SCHEMBL1765361

SCHEMBL1765361

CC(C)(C)CC[Mg]Br

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1765686 0.81
SCHEMBL582317 0.67
SCHEMBL27952993 0.65 ALDH1A1 (0.30)
SCHEMBL1654101 0.65
SCHEMBL598853 0.64 TSHR (0.46)
SCHEMBL23046 0.60
SCHEMBL374943 0.60
SCHEMBL27678783 0.60
SCHEMBL2399 0.60
Phosphine SCHEMBL1582212 0.57

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4392422-A1 EIF4E INHIBITORS AND USES THEREOF PIC Therapeutics, Inc. (US) 2024-07-03 EP disclosed
WO-2023028235-A1 EIF4E INHIBITORS AND USES THEREOF PIC Therapeutics, Inc. (US) 2023-03-02 WO disclosed
CN-115322238-A Oxysterol and methods of use thereof 萨奇治疗股份有限公司 2022-11-11 CN disclosed
EP-4058439-A1 5-MEMBERED HETEROARYLAMINOSULFONAMIDES FOR TREATING CONDITIONS MEDIATED BY DEFICIENT CFTR ACTIVITY Genzyme Corporation (US) 2022-09-21 EP disclosed
CN-115003659-A 5-membered heteroaryl amino sulfonamides for the treatment of conditions mediated by a deficiency in CFTR activity 健赞公司 2022-09-02 CN disclosed
CN-110072874-B Oxysterol and methods of use thereof 萨奇治疗股份有限公司 2022-08-12 CN disclosed
CN-114891056-A Oxysterol and methods of use thereof 萨奇治疗股份有限公司 2022-08-12 CN disclosed
US-9758480-B2 1-(cycloalkyl-carbonyl)proline derivative SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2017-09-12 US disclosed
US-9718840-B2 Condensed 5-oxazolidinone derivative SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2017-08-01 US disclosed
US-20170022218-A1 CONDENSED 5-OXAZOLIDINONE DERIVATIVE SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) 2017-01-26 US disclosed
US-20070225267-A1 3-(2-Acylamino-1-Hydroxyethyl)-Morpholine Derivatives and Their Use as Bace Inhibitors ELI LILLY AND COMPANY 2007-09-27 US disclosed
CN-1968921-A Glucagon receptor antagonists, preparation and therapeutic uses LILLY CO ELI (US) 2007-05-23 CN disclosed
EP-1758853-A1 GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES ELI LILLY AND COMPANY (US) 2007-03-07 EP disclosed
WO-2006086488-A2 SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES ELI LILLY AND COMPANY (US) 2006-08-17 WO disclosed
WO-2006034093-A2 3- (2-ACYLAMINO-1-HYDROXYETHYL)- MORPHOLINE DERIVATIVES AND THEIR USE AS BACE INHIBITORS ELLI LILLY AND COMPANY (US) 2006-03-30 WO disclosed
WO-2005123668-A1 GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES ELI LILLY AND COMPANY (US) 2005-12-29 WO disclosed
EP-1077918-B1 SYNTHESIS AND PURIFICATION OF 3,3-DIMETHYLBUTYRALDEHYDE VIA OXIDATION OF 1-CHLORO-3, 3-DIMETHYLBUTANE WITH DIMETHYL SULFOXIDE NUTRASWEET CO (US) 2005-02-23 EP disclosed
EP-1077918-A1 SYNTHESIS AND PURIFICATION OF 3,3-DIMETHYLBUTYRALDEHYDE VIA OXIDATION OF 1-CHLORO-3, 3-DIMETHYLBUTANE WITH DIMETHYL SULFOXIDE THE NUTRASWEET COMPANY (US) 2001-02-28 EP disclosed
WO-1999059951-A1 SYNTHESIS AND PURIFICATION OF 3,3-DIMETHYLBUTYRALDEHYDE VIA OXIDATION OF 1-CHLORO-3, 3-DIMETHYLBUTANE WITH DIMETHYL SULFOXIDE THE NUTRASWEET COMPANY (US) 1999-11-25 WO disclosed
US-5905175-A Synthesis and purification of 3,3-dimethylbutyraldehyde via oxidation of 1-chloro-3,3-dimethylbutane with dimethyl sulfoxide THE NUTRASWEET COMPANY (US) 1999-05-18 US disclosed