Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 16/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17654137 | 0.91 | GLS (0.45) | GLSSMN1; SMN2ATMKDM4ENPC1 | |
| SCHEMBL17654143 | 0.91 | GLS (0.45) | GLSSMN1; SMN2ATMKDM4ENPC1 | |
| SCHEMBL17654135 | 0.91 | GLS (0.45) | GLSSMN1; SMN2ATMKDM4ENPC1 | |
| SCHEMBL31083338 | 0.87 | GLS (0.46) | GLSSMN1; SMN2KDM4ENPC1ALDH1A1 | |
| SCHEMBL17654075 | 0.84 | GLS (0.44) | GLSSMN1; SMN2ATM | |
| SCHEMBL17654163 | 0.83 | GLS (0.41) | GLSSMN1; SMN2ATM | |
| SCHEMBL17654190 | 0.81 | GPR119 (0.52) | GLSHPGD | |
| SCHEMBL17654171 | 0.78 | GLS (0.41) | GLSSMN1; SMN2ATMNPC1RAB9A | |
| SCHEMBL17654116 | 0.78 | GLS (0.41) | GLSSMN1; SMN2ATMNPC1RAB9A | |
| SCHEMBL24770854 | 0.78 | SMN1; SMN2 (0.38) | GLSSMN1; SMN2KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016054388-A1 | GLUTAMINASE INHIBITORS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-04-07 | — | — | WO | disclosed |