Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKAR | P32238 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.49 |
| ▸ | NSD2 | O96028 | 1/20 | 0.45 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.45 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.45 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.45 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.45 |
| ▸ | RPA1 | P27694 | 4/20 | 0.44 |
| ▸ | SLC5A1 | P13866 | 4/20 | 0.42 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.42 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.42 |
| ▸ | MCTS1 | Q9ULC4 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12649164 | 0.91 | CCKAR (0.53) | CCKARPTGS2NSD2NSD1NSD3 | |
| SCHEMBL1765517 | 0.91 | CCKAR (0.63) | CCKARPTGS2NSD2NSD1NSD3 | |
| SCHEMBL1765034 | 0.90 | SLC5A1 (0.49) | SLC5A1 | |
| SCHEMBL1764936 | 0.90 | RPA1 (0.44) | CCKARPTGS2RPA1SLC5A1MEN1 | |
| SCHEMBL1764881 | 0.90 | CCKAR (0.43) | CCKARPTGS2RPA1SLC5A1MEN1 | |
| SCHEMBL15004300 | 0.89 | RPA1 (0.45) | CCKARPTGS2RPA1MEN1MAPT | |
| SCHEMBL1764969 | 0.89 | PTGS2 (0.48) | CCKARPTGS2RPA1MEN1MAPT | |
| SCHEMBL14780897 | 0.88 | CCKAR (0.49) | CCKARPTGS2NSD2NSD1NSD3 | |
| SCHEMBL1765015 | 0.88 | MEN1 (0.50) | RPA1MEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL1765260 | 0.87 | CCKAR (0.50) | CCKARPTGS2NSD2NSD1NSD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399682-B2 | Substituted (pyrazolylcarbonyl)imidazolidinones and their use | AICURIS GMBH & CO. KG (DE) | 2013-03-19 | — | — | US | disclosed |
| US-8399682-B2 | Substituted (pyrazolylcarbonyl)imidazolidinones and their use | AICURIS GMBH & CO. KG (DE) | 2013-03-19 | — | — | US | disclosed |
| US-20110124618-A1 | SUBSTITUTED (PYRAZOLYLCARBONYL)IMIDAZOLIDINONES AND THEIR USE | AICURIS GMBH & CO. KG (DE) | 2011-05-26 | — | — | US | disclosed |
| US-20110124618-A1 | SUBSTITUTED (PYRAZOLYLCARBONYL)IMIDAZOLIDINONES AND THEIR USE | AICURIS GMBH & CO. KG (DE) | 2011-05-26 | — | — | US | disclosed |
| WO-2009115213-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AICURIS GMBH & CO. KG (DE) | 2009-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124618-A1 | SUBSTITUTED (PYRAZOLYLCARBONYL)IMIDAZOLIDINONES AND THEIR USE | TPMT, PAICS, THPO | CCKAR 4827/4885PTGS2 3497/4885NSD2 1679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.