Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 17/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15724897 | 0.91 | GLS (0.67) | GLSALDH1A1HSD17B10 | |
| SCHEMBL15042405 | 0.90 | GLS (0.88) | GLSALDH1A1CA2 | |
| SCHEMBL14986996 | 0.89 | GLS (0.90) | GLSALDH1A1CA2 | |
| SCHEMBL21443339 | 0.86 | GLS (0.60) | GLSALDH1A1HSD17B10 | |
| SCHEMBL14987443 | 0.84 | GLS (1.00) | GLS | |
| SCHEMBL15482873 | 0.82 | GLS (0.76) | GLSALDH1A1 | |
| SCHEMBL14987001 | 0.81 | GLS (0.89) | GLSALDH1A1CA2HSD17B10 | |
| SCHEMBL15727744 | 0.81 | GLS (0.89) | GLSALDH1A1CA2HSD17B10 | |
| SCHEMBL14987261 | 0.79 | GLS (0.83) | GLS | |
| SCHEMBL14987278 | 0.78 | GLS (0.72) | GLSALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9303002-B2 | Compounds and their methods of use | AGIOS PHARMACEUTICALS, INC. (US) | 2016-04-05 | — | — | US | disclosed |
| US-9303002-B2 | Compounds and their methods of use | AGIOS PHARMACEUTICALS, INC. (US) | 2016-04-05 | — | — | US | disclosed |