Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 19/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15724897 | 0.94 | GLS (0.67) | GLSALDH1A1HPGDHSD17B10 | |
| SCHEMBL17655079 | 0.86 | GLS (0.71) | GLSALDH1A1HSD17B10 | |
| SCHEMBL14987619 | 0.76 | GLS (1.00) | GLSALDH1A1HPGDHSD17B10 | |
| SCHEMBL21369061 | 0.76 | GLS (0.78) | GLSALDH1A1HPGDHSD17B10 | |
| SCHEMBL15042405 | 0.74 | GLS (0.88) | GLSALDH1A1 | |
| SCHEMBL14987651 | 0.73 | RECQL (0.76) | GLSALDH1A1HPGDHSD17B10 | |
| SCHEMBL14986996 | 0.72 | GLS (0.90) | GLSALDH1A1 | |
| SCHEMBL21443392 | 0.72 | GLS (0.65) | GLS | |
| SCHEMBL14987284 | 0.71 | GLS (0.79) | GLS | |
| SCHEMBL21443507 | 0.70 | GLS (0.55) | GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922832-B1 | GLUTAMINASE INHIBITORS AND METHODS OF USE | AGIOS PHARMACEUTICALS INC (US) | 2019-10-09 | — | — | EP | disclosed |