Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15997195 | 0.86 | SMN1; SMN2 (0.40) | SMN1; SMN2CYP1A2TSHRLMNAPOLB | |
| SCHEMBL15997242 | 0.85 | LMNA (0.41) | SMN1; SMN2CYP4F2CYP4A11CYP1A2TSHR | |
| SCHEMBL14905952 | 0.84 | SMN1; SMN2 (0.39) | SMN1; SMN2CYP1A2TSHRLMNAPOLB | |
| SCHEMBL14905949 | 0.83 | SMN1; SMN2 (0.45) | SMN1; SMN2CYP4F2CYP4A11CYP1A2TSHR | |
| SCHEMBL15987580 | 0.76 | CA12 (0.42) | SMN1; SMN2CYP4F2CYP4A11CYP1A2TSHR | |
| SCHEMBL15987339 | 0.74 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP4F2CYP4A11CYP1A2TSHR | |
| SCHEMBL15997274 | 0.73 | SMN1; SMN2 (0.43) | SMN1; SMN2CYP4F2CYP4A11CYP1A2TSHR | |
| SCHEMBL15997231 | 0.73 | SMN1; SMN2 (0.40) | SMN1; SMN2CYP4F2CYP4A11CYP1A2TSHR | |
| Succinic Acid Diethyl Ester SCHEMBL4430582 | 0.72 | GAA (0.57) | SMN1; SMN2CYP4F2CYP4A11CYP1A2TSHR | |
| SCHEMBL15987472 | 0.71 | SMN1; SMN2 (0.41) | SMN1; SMN2CYP4F2CYP4A11CYP1A2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2772490-B1 | AMINOALKYL-SUBSTITUTED N-THIENYL BENZAMIDE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2016-04-06 | — | — | EP | disclosed |