Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.47 |
| ▸ | NPC1 | O15118 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.47 |
| ▸ | METAP1 | P53582 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2657025 | 0.83 | CYP1A2 (0.62) | RAB9ANPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL24593307 | 0.71 | HDAC3 (0.45) | RAB9ANPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL15113503 | 0.70 | CYP3A4 (0.70) | SMN1; SMN2MAPTHTTKDM4EHPGD | |
| SCHEMBL1520080 | 0.69 | IDO1 (0.55) | RAB9ANPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL13134183 | 0.67 | HDAC3 (0.53) | RAB9ANPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL13075600 | 0.65 | — | — | |
| SCHEMBL1007731 | 0.64 | HDAC3 (0.64) | RAB9ANPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL1897970 | 0.64 | NPC1 (1.00) | RAB9ANPC1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL28232715 | 0.63 | PDPK1 (0.48) | RAB9AMAPTKDM4EALDH1A1KAT2A | |
| SCHEMBL26854309 | 0.62 | NPC1 (0.73) | RAB9ANPC1SMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2244706-B1 | GLUCOKINASE ACTIVATORS | MERCK PATENT GMBH (DE) | 2016-04-06 | — | — | EP | disclosed |