Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 1.00 |
| ▸ | RAB9A | P51151 | 6/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | METAP2 | P50579 | 1/20 | 1.00 |
| ▸ | METAP1 | P53582 | 1/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | SCD | O00767 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29074202 | 0.86 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2LMNAMETAP2 | |
| SCHEMBL995829 | 0.81 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2LMNAMETAP2 | |
| SCHEMBL7868117 | 0.81 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2LMNAMETAP2 | |
| Hydrochloric Acid SCHEMBL27594584 | 0.80 | NPC1 (0.97) | NPC1RAB9ASMN1; SMN2LMNAMETAP2 | |
| SCHEMBL27702357 | 0.80 | NPC1 (0.72) | NPC1RAB9ASMN1; SMN2LMNAMETAP2 | |
| SCHEMBL8895139 | 0.79 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2LMNAMETAP2 | |
| SCHEMBL6056917 | 0.79 | SMN1; SMN2 (0.63) | NPC1RAB9ASMN1; SMN2LMNAMETAP2 | |
| SCHEMBL27965261 | 0.79 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2LMNAMETAP2 | |
| SCHEMBL27622181 | 0.78 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2LMNAMETAP2 | |
| Bromide SCHEMBL27891481 | 0.78 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2LMNAMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108864073-B | N-thiazolyl pyridine carboxamide derivative and preparation method and application thereof | 湖南大学 | 2020-08-18 | — | — | CN | claimed |
| CN-108864073-A | N- thiazolyl derivative of pyridine carboxamide and the preparation method and application thereof | 湖南大学 | 2018-11-23 | — | — | CN | claimed |
| CN-108864073-B | N-thiazolyl pyridine carboxamide derivative and preparation method and application thereof | 湖南大学 | 2020-08-18 | — | — | CN | disclosed |
| CN-108864073-A | N- thiazolyl derivative of pyridine carboxamide and the preparation method and application thereof | 湖南大学 | 2018-11-23 | — | — | CN | disclosed |
| US-9868730-B2 | Kappa opioid receptor selective compounds, compositions, and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-01-16 | — | — | US | disclosed |
| US-20160002216-A1 | KAPPA OPIOID RECEPTOR SELECTIVE COMPOUNDS, COMPOSITIONS, AND USES THEREOF | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 2016-01-07 | — | — | US | disclosed |
| WO-2014127256-A1 | KAPPA OPIOID RECEPTOR SELECTIVE COMPOUNDS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-08-21 | — | — | WO | disclosed |
| US-8344003-B2 | 2-pyridinecarboxamide derivatives | MSD K. K. (JP) | 2013-01-01 | — | — | US | disclosed |
| US-20110213000-A1 | N-(2-THIAZOLYL)-AMIDE DERIVATIVES FOR THE TREATMENT OF OBESITY, DIABETES AND CARDIOVASCULAR DISEASES | ZELTIA, S.A. (ES) | 2011-09-01 | — | — | US | disclosed |
| US-20110213000-A1 | N-(2-THIAZOLYL)-AMIDE DERIVATIVES FOR THE TREATMENT OF OBESITY, DIABETES AND CARDIOVASCULAR DISEASES | ZELTIA, S.A. (ES) | 2011-09-01 | — | — | US | disclosed |
| US-20110213000-A1 | N-(2-THIAZOLYL)-AMIDE DERIVATIVES FOR THE TREATMENT OF OBESITY, DIABETES AND CARDIOVASCULAR DISEASES | ZELTIA, S.A. (ES) | 2011-09-01 | — | — | US | disclosed |
| EP-2175852-A1 | N-(2-THIAZOLYL)-AMIDE DERIVATIVES FOR THE TREATMENT OF OBESITY, DIABETES AND CARDIOVASCULAR DISEASES | Zeltia, S.A. (ES) | 2010-04-21 | — | — | EP | disclosed |
| US-20100041660-A1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | MSD K.K. (JP) | 2010-02-18 | — | — | US | disclosed |
| WO-2009064388-A2 | INHIBITORS OF HUMAN METHIONINE AMINOPEPTIDASE 1 AND METHODS OF TREATING DISORDERS | LIU JUN O (US) | 2009-05-22 | — | — | WO | disclosed |
| WO-2009019202-A1 | N-(2-THIAZOLYL)-AMIDE DERIVATIVES FOR THE TREATMENT OF OBESITY, DIABETES AND CARDIOVASCULAR DISEASES | ZELTIA, S.A. (ES) | 2009-02-12 | — | — | WO | disclosed |
| WO-2009019202-A1 | N-(2-THIAZOLYL)-AMIDE DERIVATIVES FOR THE TREATMENT OF OBESITY, DIABETES AND CARDIOVASCULAR DISEASES | ZELTIA, S.A. (ES) | 2009-02-12 | — | — | WO | disclosed |
| EP-2020232-A1 | N-(1-thiazolyl)-amide derivatives for the treatment of obesity, diabetes and cardiovascular diseases | Zeltia, S.A. (ES) | 2009-02-04 | — | — | EP | disclosed |
| EP-2020232-A1 | N-(1-thiazolyl)-amide derivatives for the treatment of obesity, diabetes and cardiovascular diseases | Zeltia, S.A. (ES) | 2009-02-04 | — | — | EP | disclosed |
| CN-100378094-C | Novel 2-pyridinecarboxamide derivatives | BANYU PHARMA CO LTD (JP) | 2008-04-02 | — | — | CN | disclosed |
| CN-1747951-A | Novel 2-pyridinecarboxamide derivatives | BANYU PHARMA CO LTD (JP) | 2006-03-15 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002216-A1 | KAPPA OPIOID RECEPTOR SELECTIVE COMPOUNDS, COMPOSITIONS, AND USES THEREOF | OPRK1, OPRL1, OPRM1 | NPC1 957/4885RAB9A 2616/4885SMN1; SMN2 1941/4885 |
| US-20110213000-A1 | N-(2-THIAZOLYL)-AMIDE DERIVATIVES FOR THE TREATMENT OF OBESITY, DIABETES AND CARDIOVASCULAR DISEASES | ADIPOR1, ADIPOR2, FABP4 | NPC1 649/4885RAB9A 3230/4885SMN1; SMN2 2864/4885 |
| US-20100041660-A1 | NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES | GCKR, GCK, HK2 | NPC1 4261/4885RAB9A 3609/4885SMN1; SMN2 4125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.