Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 8/20 | 0.61 |
| ▸ | NPC1 | O15118 | 8/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | METAP2 | P50579 | 1/20 | 0.61 |
| ▸ | METAP1 | P53582 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 5/20 | 0.60 |
| ▸ | HTT | P42858 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.60 |
| ▸ | RELA | Q04206 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17655802 | 0.83 | RAB9A (0.47) | CYP1A2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL15113503 | 0.82 | CYP3A4 (0.70) | SMN1; SMN2L3MBTL1ALDH1A1HPGDHTT | |
| SCHEMBL3278951 | 0.77 | CYP1A2 (0.73) | CYP1A2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL5206561 | 0.77 | CYP1A2 (1.00) | CYP1A2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL20541971 | 0.76 | HDAC3 (0.68) | CYP1A2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL1897970 | 0.76 | NPC1 (1.00) | CYP1A2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL11509919 | 0.76 | NPC1 (0.70) | CYP1A2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL1606455 | 0.76 | NPC1 (0.79) | CYP1A2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL24072353 | 0.75 | CYP3A4 (0.81) | CYP1A2RAB9ANPC1SMN1; SMN2LMNA | |
| SCHEMBL30339352 | 0.75 | NPC1 (1.00) | CYP1A2RAB9ANPC1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100331338-A1 | Glucokinase Activators | MERCK PATENT GMBH (DE) | 2010-12-30 | — | — | US | claimed |
| EP-2244706-A1 | GLUCOKINASE ACTIVATORS | Merck Patent GmbH (DE) | 2010-11-03 | — | — | EP | claimed |
| WO-2009106203-A1 | GLUCOKINASE ACTIVATORS | MERCK PATENT GMBH (DE) | 2009-09-03 | — | — | WO | claimed |
| EP-2244706-B1 | GLUCOKINASE ACTIVATORS | MERCK PATENT GMBH (DE) | 2016-04-06 | — | — | EP | disclosed |
| US-20100331338-A1 | Glucokinase Activators | MERCK PATENT GMBH (DE) | 2010-12-30 | — | — | US | disclosed |
| US-20100331338-A1 | Glucokinase Activators | MERCK PATENT GMBH (DE) | 2010-12-30 | — | — | US | disclosed |
| US-20100331338-A1 | Glucokinase Activators | MERCK PATENT GMBH (DE) | 2010-12-30 | — | — | US | disclosed |
| EP-2244706-A1 | GLUCOKINASE ACTIVATORS | Merck Patent GmbH (DE) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009106203-A1 | GLUCOKINASE ACTIVATORS | MERCK PATENT GMBH (DE) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009106203-A1 | GLUCOKINASE ACTIVATORS | MERCK PATENT GMBH (DE) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100331338-A1 | Glucokinase Activators | GCKR, HK1, GCK | CYP1A2 1182/4885RAB9A 2651/4885NPC1 1277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.