Sugi Predict

Sugi Predict / Compounds / SCHEMBL1765638

SCHEMBL1765638

SCHEMBL1765638

Oc1ccc(C2CC2)nc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ OPRM1 P35372 1/20 0.46
▸ OPRL1 P41146 1/20 0.46
▸ NOTUM Q6P988 2/20 0.43
▸ DRD4 P21917 1/20 0.42
▸ MEN1 O00255 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ L3MBTL1 Q9Y468 1/20 0.41
▸ DEGS1 O15121 3/20 0.41
▸ FYN P06241 1/20 0.40
▸ ESR2 Q92731 4/20 0.39
▸ USP7 Q93009 2/20 0.38
▸ CCR2 P41597 2/20 0.36
▸ KCNH2 Q12809 2/20 0.36
▸ ESR1 P03372 1/20 0.35
▸ CYP3A4 P08684 1/20 0.35
▸ CYP2C9 P11712 1/20 0.35
▸ MIF P14174 1/20 0.35
▸ MAPK8 P45983 1/20 0.34
▸ MAPK10 P53779 1/20 0.34
▸ CCRL2 O00421 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29410679 1.00 OPRM1 (0.46) OPRM1OPRL1NOTUMDRD4MEN1
SCHEMBL29526783 0.91 OPRM1 (0.43) OPRM1OPRL1NOTUMDRD4MEN1
SCHEMBL1765046 0.91 DEGS1 (0.44) OPRM1OPRL1NOTUMDRD4MEN1
SCHEMBL6253868 0.90 OPRM1 (0.41) OPRM1OPRL1NOTUMDRD4MEN1
SCHEMBL6253871 0.90 OPRM1 (0.41) OPRM1OPRL1NOTUMDRD4MEN1
SCHEMBL3143337 0.90 DEGS1 (0.47) OPRM1OPRL1NOTUMDRD4MEN1
SCHEMBL29400886 0.86 USP7 (0.50) OPRM1OPRL1NOTUMDRD4MEN1
SCHEMBL18740585 0.86 USP7 (0.50) OPRM1OPRL1NOTUMDRD4MEN1
SCHEMBL25213167 0.86 OPRM1 (0.39) OPRM1OPRL1NOTUMDRD4MEN1
SCHEMBL6256950 0.86 DRD4 (0.41) OPRM1OPRL1NOTUMDRD4MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3704094-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2026-03-11 — — EP disclosed
US-20250122188-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2025-04-17 — — US disclosed
US-20250115563-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC 2025-04-10 — — US disclosed
US-20240166652-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ABBVIE INC. 2024-05-23 — — US disclosed
EP-4356971-A2 MODULATORS OF THE INTEGRATED STRESS PATHWAY Calico Life Sciences LLC (US) 2024-04-24 — — EP disclosed
EP-3704098-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2024-01-24 — — EP disclosed
CN-112154142-B Modulators of integrated stress pathways 卡里科生命科学有限责任公司 2023-11-21 — — CN disclosed
US-20230265098-A1 ALKYNE QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 ENLIVEN INC. 2023-08-24 — — US disclosed
US-20230265098-A1 ALKYNE QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 ENLIVEN INC. 2023-08-24 — — US disclosed
US-20230265098-A1 ALKYNE QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 ENLIVEN INC. 2023-08-24 — — US disclosed
WO-2017193034-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES (US) 2017-11-09 — — WO disclosed
US-20170121314-A1 HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES Grünenthal GmbH (DE) 2017-05-04 — — US disclosed
EP-3131894-A1 HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES Grünenthal GmbH (DE) 2017-02-22 — — EP disclosed
CN-106458956-A Heteroaryl substituted heterocyclyl sulfones 格吕伦塔尔有限公司 2017-02-22 — — CN disclosed
WO-2015158427-A1 HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES Grünenthal GmbH (DE) 2015-10-22 — — WO disclosed
US-20150291572-A1 HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES Grünenthal GmbH (DE) 2015-10-15 — — US disclosed
US-20110124661-A1 OXAZOLOBENZIMIDAZOLE DERIVATIVES MERCK SHARP & DOHME CORP. 2011-05-26 — — US disclosed
US-20110124661-A1 OXAZOLOBENZIMIDAZOLE DERIVATIVES MERCK SHARP & DOHME CORP. 2011-05-26 — — US disclosed
US-20110124661-A1 OXAZOLOBENZIMIDAZOLE DERIVATIVES MERCK SHARP & DOHME CORP. 2011-05-26 — — US disclosed
WO-2009140163-A1 OXAZOLOBENZIMIDAZOLE DERIVATIVES MERCK & CO., INC. (US) 2009-11-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250122188-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 OPRM1 1904/4885OPRL1 1255/4885NOTUM 4143/4885
US-20170121314-A1 HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES TRPV1, CACNA1B, CACNA1C OPRM1 169/4885OPRL1 93/4885NOTUM 3275/4885
US-20150291572-A1 HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES TRPV1, CACNA1B, CACNA1C OPRM1 169/4885OPRL1 93/4885NOTUM 3275/4885
US-20240166652-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 OPRM1 1904/4885OPRL1 1255/4885NOTUM 4143/4885
US-20110124661-A1 OXAZOLOBENZIMIDAZOLE DERIVATIVES GRM2, GRM1, GRM3 OPRM1 178/4885OPRL1 79/4885NOTUM 3160/4885
US-20230265098-A1 ALKYNE QUINAZOLINE DERIVATIVES AS INHIBITORS OF ERBB2 ERBB2, ERBB3, CHEK2 OPRM1 1909/4885OPRL1 1385/4885NOTUM 3726/4885
US-20250115563-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 OPRM1 1904/4885OPRL1 1255/4885NOTUM 4143/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.