Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 9/20 | 0.47 |
| ▸ | CLK3 | P49761 | 9/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.47 |
| ▸ | WNT1 | P04628 | 9/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12397469 | 0.92 | CLK2 (0.56) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL12396623 | 0.92 | CLK2 (0.47) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL12397361 | 0.91 | CLK2 (0.49) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL19499523 | 0.90 | WNT1 (0.54) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL12395407 | 0.89 | WNT1 (0.47) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL20041563 | 0.89 | CLK2 (0.59) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL12396628 | 0.88 | CLK2 (0.47) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL15617343 | 0.87 | CLK2 (0.61) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL12395405 | 0.87 | WNT1 (0.56) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL12396633 | 0.86 | WNT1 (0.46) | CLK2CLK3DYRK1AWNT1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3001903-B1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | SAMUMED LLC (US) | 2017-10-25 | — | — | EP | disclosed |
| EP-3001903-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | Samumed, LLC (US) | 2016-04-06 | — | — | EP | disclosed |