Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 11/20 | 0.59 |
| ▸ | CLK3 | P49761 | 11/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 11/20 | 0.59 |
| ▸ | WNT1 | P04628 | 10/20 | 0.58 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.58 |
| ▸ | CLK1 | P49759 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12369996 | 0.93 | CLK2 (0.59) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL12370019 | 0.92 | CLK2 (0.69) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL12369960 | 0.92 | CLK2 (0.58) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL15617350 | 0.90 | WNT1 (0.68) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL12369986 | 0.90 | WNT1 (0.58) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL17565045 | 0.90 | CLK2 (0.58) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL19498781 | 0.89 | CLK2 (0.52) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL17656552 | 0.89 | CLK2 (0.47) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL19497965 | 0.89 | CLK2 (0.72) | CLK2CLK3DYRK1AWNT1TGFBR1 | |
| SCHEMBL12370006 | 0.88 | CLK2 (0.60) | CLK2CLK3DYRK1AWNT1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305073-A1 | 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF | Samumed, LLC (US) | 2018-04-11 | — | — | EP | disclosed |