Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 3/20 | 0.63 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.63 |
| ▸ | DRD2 | P14416 | 2/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 2/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12526363 | 0.85 | DRD2 (0.56) | ITGB3ITGA2BDRD2DRD3DRD4 | |
| SCHEMBL4021071 | 0.84 | DRD2 (0.68) | ITGB3ITGA2BDRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL10713081 | 0.84 | DRD4 (0.68) | ITGB3ITGA2BDRD2DRD3DRD4 | |
| SCHEMBL1066467 | 0.82 | HTR2A (0.72) | ITGB3ITGA2BDRD4HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL4653252 | 0.81 | HTR2A (0.71) | ITGB3ITGA2BDRD4HTR2AHTR2C | |
| SCHEMBL27519383 | 0.80 | HDAC4 (0.71) | SMN1; SMN2KDM4EMAPTTSHRCYP2D6 | |
| SCHEMBL17656756 | 0.79 | AOC3 (0.55) | DRD2DRD3DRD4TSHRHSD17B10 | |
| SCHEMBL31593043 | 0.79 | CYP2D6 (0.69) | ITGB3ITGA2BDRD2DRD3DRD4 | |
| SCHEMBL27040086 | 0.79 | CYP2D6 (0.69) | ITGB3ITGA2BDRD2DRD3DRD4 | |
| SCHEMBL10074441 | 0.78 | HDAC1 (0.62) | SMN1; SMN2KDM4EMAPTCYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2695881-B1 | GUANIDINE COMPOUND | ASTELLAS PHARMA INC (JP) | 2016-04-27 | — | — | EP | disclosed |
| EP-3002278-A1 | GUANIDINE COMPOUND | Astellas Pharma Inc. (JP) | 2016-04-06 | — | — | EP | disclosed |