SCHEMBL17656758

SCHEMBL17656758

CNC(=O)CNc1ncc(-c2cccc(CNC(=O)NC(=N)N)c2)cn1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 3/20 0.40
VEGFA P15692 1/20 0.38
FLT1 P17948 1/20 0.38
EGLN1 Q9GZT9 1/20 0.38
EGLN3 Q9H6Z9 1/20 0.38
PADI3 Q9ULW8 3/20 0.37
PADI1 Q9ULC6 2/20 0.37
PPID Q08752 1/20 0.37
ATG4B Q9Y4P1 1/20 0.37
CYP4F2 P78329 1/20 0.36
CYP4A11 Q02928 1/20 0.36
IKBKB O14920 1/20 0.35
CHUK O15111 1/20 0.35
VNN1 O95497 1/20 0.35
SRC P12931 1/20 0.35
MAP4K4 O95819 1/20 0.34
PADI4 Q9UM07 2/20 0.34
PADI2 Q9Y2J8 1/20 0.34
MAPK1 P28482 1/20 0.34
F7 P08709 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16785053 0.90 AOC3 (0.40) AOC3PADI3PADI1PPIDATG4B
SCHEMBL16785200 0.87 PPID (0.38) AOC3PADI3PADI1PPIDATG4B
SCHEMBL16785060 0.85 PADI3 (0.41) AOC3PADI3PADI1ATG4BCYP4F2
SCHEMBL18757106 0.84 PSMB1 (0.36) AOC3PADI3PADI1PPIDATG4B
SCHEMBL16785199 0.84 PADI3 (0.39) AOC3PADI3PADI1ATG4BCYP4F2
SCHEMBL16785193 0.84 PADI3 (0.41) AOC3PADI3PADI1PPIDATG4B
SCHEMBL18756976 0.83 AOC3 (0.43) AOC3PADI3PADI1PPIDATG4B
SCHEMBL12525772 0.83 PADI3 (0.40) AOC3PADI3PADI1ATG4BCYP4F2
SCHEMBL16785035 0.83 SMN1; SMN2 (0.48) VNN1HDAC3HDAC1HDAC2HDAC6
SCHEMBL16784928 0.82 SYK (0.38) AOC3PADI3PADI1ATG4BCYP4F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3002278-B1 GUANIDINE COMPOUND ASTELLAS PHARMA INC (JP) 2017-04-19 EP disclosed
US-9556160-B2 Guanidine compound ASTELLAS PHARMA INC. (JP) 2017-01-31 US disclosed
EP-2695881-B1 GUANIDINE COMPOUND ASTELLAS PHARMA INC (JP) 2016-04-27 EP disclosed
EP-3002278-A1 GUANIDINE COMPOUND Astellas Pharma Inc. (JP) 2016-04-06 EP disclosed