PADI3 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL1979695	0.56	6/20
SCHEMBL13560779	0.55	6/20
SCHEMBL1979577	0.63	5/20
SCHEMBL1981102	0.58	5/20
SCHEMBL12598887	0.52	5/20
SCHEMBL3421753	0.51	5/20
SCHEMBL4020010	0.47	5/20
SCHEMBL6701286	0.46	5/20
SCHEMBL4729919	1.00	4/20
SCHEMBL459004	0.69	4/20
SCHEMBL1979621	0.66	4/20
SCHEMBL158990	0.60	4/20
SCHEMBL10946109	0.60	4/20
SCHEMBL16396984	0.47	4/20
SCHEMBL8485286	0.46	4/20
SCHEMBL8487988	0.46	4/20
Trifluoroacetic Acid (SCHEMBL8528372)	0.46	4/20
SCHEMBL8485159	0.46	4/20
SCHEMBL8487272	0.46	4/20
SCHEMBL8484533	0.45	4/20

Clinical trials — most relevant to PADI3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
L-arginine Treatment in Mild Hypertension	PHASE4	UNKNOWN
Vascular Function Intervention Trial in Sickle Cell Disease	PHASE2/PHASE3	UNKNOWN
L-Arginine in Pre-Eclampsia	PHASE3	COMPLETED
Efficacy and Safety of Pegzilarginase in Patients With Arginase 1 Deficiency	PHASE3	COMPLETED
Effect of Rosiglitazone on ADMA in Critical Illness	PHASE3	UNKNOWN
Sickle Cell Disease Treatment With Arginine Therapy (STArT) Trial	PHASE3	COMPLETED
A Study to Investigate Efficacy and Safety of AZD1163 in Participants With Rheumatoid Arthritis	PHASE2	RECRUITING
Intravenous L-Citrulline Influence on the Need for Invasive Mechanical Ventilation for Acute Hypoxemic Respiratory Failure in Patients With COVID-19	PHASE2	COMPLETED
ADI-PEG20, Obesity and Prediabetes	PHASE2	WITHDRAWN
Arginine Treatment of Acute Chest Syndrome (Pneumonia) in Sickle Cell Disease Patients	PHASE2	COMPLETED
The Effects of NOx and Conjugated Linoleic Acid on Asthmatics	PHASE2	COMPLETED
iNOS With Positron Emission Tomography (PET) in Cellular Inflammation.	EARLY_PHASE1	COMPLETED
Effect of Nonsurgical Periodontal Therapy (NSPT) on Rheumatoid Arthritis Subjects With Periodontitis	nan	COMPLETED
Study of the Articular Microbiota in Rheumatoid Arthritis.	nan	COMPLETED
Serum Anti-PCOLCE as Novel Diagnostic Biomarker in Rheumatoid Arthritis With Emphasis on Seronegative Patients.	nan	NOT_YET_RECRUITING
Impact of Antiglycemic & Immunosuppressive Therapies on NETosis in Diabetes & Kidney Disease (NETs - Neutrophil Traps)	nan	RECRUITING
Clinical Trial for Evaluation of Vermillion's Blood Test to Predict the Probability of Peripheral Artery Disease	nan	COMPLETED
Effects of Trehalose and Polyphenols in Vasculopathic Patients	nan	COMPLETED
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients	nan	COMPLETED
Full Mouth Disinfection and Antibiotics for Periodontitis in High or Moderate Disease Activity Rheumatoid Arthritis	nan	COMPLETED
Study of Arginine and Nitric Oxide in Patients With Diabetes	nan	COMPLETED
Effect Assessment of Periodontal Prophylaxis on Rheumatoid Arthritis Activity.	nan	COMPLETED
Nitric Oxide Supplementation on Neurocognitive Functions in Patients With ASLD	nan	COMPLETED
Effect of Arginine and Glutamine on Radiation-induced Oral Mucositis: a Trible Blinded Randomized Controlled Clinical Trial	nan	COMPLETED
L-Arginine, Symmetrical and Asymmetrical Dimethylarginine (SDMA/ADMA) in Acute Kidney Injury (AKI)	nan	COMPLETED
Arginine Synthesis in Healthy Adult Humans	nan	COMPLETED
Preterm Arginine INTake Study	nan	COMPLETED
The Clinical Value of the Nitric Oxide System Components in Asthma and COPD	nan	UNKNOWN
Evaluation of Biomarker Levels in Gingival Crevicular Fluid of Patients With Different Periodontal Diseases	nan	COMPLETED
Rheumatoid Arthritis Patients and Porphyromonas Gingivalis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PADI3 binder may also engage these)

Protein	Name	Similarity
Q9Z184	—	1.000	Q9Z184 →
PADI2	Protein-arginine deiminase type-2	1.000	landscape →
P70708	—	1.000	P70708 →
PADI1	Protein-arginine deiminase type-1	1.000	landscape →
O02849	—	1.000	O02849 →
PADI4	Protein-arginine deiminase type-4	0.998	landscape →
P20717	—	0.997	P20717 →
Q9Z185	—	0.997	Q9Z185 →
Q08642	—	0.997	Q08642 →
O88807	—	0.996	O88807 →
O88806	—	0.995	O88806 →
Q8K3V4	—	0.993	Q8K3V4 →
PADI6	Inactive protein-arginine deiminase type-6	0.990	landscape →
Q9Z183	—	0.990	Q9Z183 →
Q9STV0	—	0.984	Q9STV0 →
Q9D5Z5	—	0.982	Q9D5Z5 →
A4IFB4	—	0.982	A4IFB4 →
AS3MT	Arsenite methyltransferase	0.982	landscape →
KDM5B	Lysine-specific demethylase 5B	0.982	landscape →
Q6W3E5	—	0.981	Q6W3E5 →
KDM5D	Lysine-specific demethylase 5D	0.981	landscape →
P06623	—	0.981	P06623 →
Q7TNB8	—	0.981	Q7TNB8 →
RIMKLA	N-acetylaspartylglutamate synthase A	0.981	landscape →
Q811U4	—	0.981	Q811U4 →
Q9W2W5	—	0.980	Q9W2W5 →
Q5XHF8	—	0.980	Q5XHF8 →
Q61586	—	0.980	Q61586 →
A8E7C5	—	0.980	A8E7C5 →
Q8VHT6	—	0.980	Q8VHT6 →