Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL1766153

N.N.N[C@H]1CCCC[C@@H]1N

nearest known ligand 0.91

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.91
MEN1 O00255 1/20 0.91
KMT2A Q03164 1/20 0.91
ALDH1A1 P00352 1/20 0.36
MMP2 P08253 2/20 0.32
MMP9 P14780 2/20 0.32
CA12 O43570 2/20 0.32
CA1 P00915 2/20 0.32
CA2 P00918 2/20 0.32
CA9 Q16790 2/20 0.32
MMP1 P03956 1/20 0.32
MMP3 P08254 1/20 0.32
MMP8 P22894 1/20 0.32
MMP13 P45452 1/20 0.32
TSHR P16473 1/20 0.31
NOS2 P35228 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL9478481 1.00
Ammonia Solution, Strong SCHEMBL7559572 1.00 THRB (0.91) THRBMEN1KMT2AALDH1A1MMP2
SCHEMBL1155588 0.95 THRB (1.00) THRBMEN1KMT2AALDH1A1MMP2
SCHEMBL358444 0.95
SCHEMBL29457 0.95
SCHEMBL354568 0.95
SCHEMBL73951 0.95
SCHEMBL1107195 0.95
SCHEMBL29582773 0.95
SCHEMBL73950 0.95

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2855494-B1 IRON CATALYSTS WITH UNSYMMETRICAL PNN'P LIGANDS GOVERNING COUNCIL UNIV TORONTO (CA) 2020-12-23 EP disclosed
US-9597673-B2 Iron catalysts with unsymmetrical PNN'P ligands THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2017-03-21 US disclosed
US-20150151289-A1 IRON CATALYSTS WITH UNSYMMETRICAL PNN'P LIGANDS GOVERING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2015-06-04 US disclosed
EP-2855494-A1 IRON CATALYSTS WITH UNSYMMETRICAL PNN'P LIGANDS The Governing Council of the University of Toronto (CA) 2015-04-08 EP disclosed
WO-2013173930-A1 IRON CATALYSTS WITH UNSYMMETRICAL PNN'P LIGANDS THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2013-11-28 WO disclosed
EP-2319825-A1 ENZYMATIC SYNTHESIS OF ENANTIOMERICALLY ENRICHED DERIVATIVES OF CIS- AND TRANS-CYCLOPENTANE-1,2-DIAMINES EntreChem, S.L. (ES) 2011-05-11 EP disclosed
US-6660884-B2 Catalyst promote synthesis of tertiary alcohols with enantioselectivity; Bicyclo(2.2.1)heptane-1-methane sulfonamide-N,N'-(1S,2S)-1,2-cyclohexanediylbis(2-hydroxy-7,7-dimethyl) -(1R,1'R,2S,2'S,4S,4'S) THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA 2003-12-09 US disclosed
US-20030191345-A1 CATALYSTS, METHODS FOR MAKING SAID CATALYSTS, AND METHODS FOR MAKING CHIRAL COMPOUNDS WITH HIGH ENANTIOSELECTIVITY TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE 2003-10-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150151289-A1 IRON CATALYSTS WITH UNSYMMETRICAL PNN'P LIGANDS PNN, NCL, IDH2 THRB 4691/4885MEN1 2013/4885KMT2A 1312/4885
US-20030191345-A1 CATALYSTS, METHODS FOR MAKING SAID CATALYSTS, AND METHODS FOR MAKING CHIRAL COMPOUNDS WITH HIGH ENANTIOSELECTIVITY COASY, HMGCR, ALKBH1 THRB 4841/4885MEN1 1127/4885KMT2A 535/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.