Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | APLNR | P35414 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | VNN1 | O95497 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17663971 | 0.84 | HSP90AB1 (0.47) | ALDH1A1MAPK1 | |
| SCHEMBL17663975 | 0.81 | RAB9A (0.48) | SMN1; SMN2LMNATSHRMAPK1POLB | |
| SCHEMBL18666584 | 0.80 | MAOB (0.51) | ALDH1A1SMN1; SMN2LMNALTA4HPOLB | |
| SCHEMBL18641217 | 0.80 | LTA4H (0.46) | ALDH1A1SMN1; SMN2LMNALTA4HPOLB | |
| Hydrochloric Acid SCHEMBL18640992 | 0.79 | MAOB (0.54) | ALDH1A1SMN1; SMN2LMNALTA4HPOLB | |
| SCHEMBL14880495 | 0.78 | LTA4H (0.65) | ALDH1A1SMN1; SMN2LMNAMAPTLTA4H | |
| Hydrochloric Acid SCHEMBL28230990 | 0.78 | SAE1 (0.46) | ALDH1A1SMN1; SMN2LMNAMAPTLTA4H | |
| SCHEMBL13567976 | 0.76 | GAA (0.47) | ALDH1A1MAPTNFE2L2VNN1 | |
| SCHEMBL23742238 | 0.75 | APP (0.44) | ALDH1A1SMN1; SMN2LMNAMAPTLTA4H | |
| SCHEMBL17479156 | 0.75 | MAPT (0.46) | MAPTLTA4HTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3209732-B1 | SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS | SCRIPPS RESEARCH INST (US) | 2021-08-04 | — | — | EP | disclosed |
| WO-2016053855-A1 | SPHINGOSINE-1-PHOSPATE RECEPTOR MODULATORS FOR TREATMENT OF CARDIOPULMONARY DISORDERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-04-07 | — | — | WO | disclosed |