Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17651987 | 0.91 | TDO2 (0.50) | TDO2IDO1 | |
| SCHEMBL17665352 | 0.87 | TDO2 (0.47) | TDO2IDO1 | |
| SCHEMBL17651977 | 0.86 | TDO2 (0.46) | TDO2IDO1LMNA | |
| SCHEMBL17651935 | 0.86 | TDO2 (0.46) | TDO2IDO1 | |
| SCHEMBL17652000 | 0.86 | TDO2 (0.46) | TDO2IDO1CYP19A1CYP11B2 | |
| SCHEMBL17651995 | 0.86 | TDO2 (0.46) | TDO2IDO1CYP11B2 | |
| SCHEMBL17665348 | 0.82 | IKBKB (0.45) | TDO2IDO1CYP17A1 | |
| SCHEMBL17665353 | 0.82 | TDO2 (0.45) | TDO2IDO1 | |
| SCHEMBL17665357 | 0.81 | TDO2 (0.46) | TDO2IDO1 | |
| SCHEMBL17665475 | 0.80 | TDO2 (0.43) | TDO2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016051181-A1 | 4H-IMIDAZO[1,5-A]INDOLE DERIVATIVES AND THEIR USE AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) AND/OR TRYPTOPHAN 2,3-DIOXYGENASE (TD02) MODULATORS | REDX PHARMA PLC (GB) | 2016-04-07 | — | — | WO | disclosed |