Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17651987 | 0.90 | TDO2 (0.50) | TDO2IDO1 | |
| SCHEMBL17651935 | 0.88 | TDO2 (0.46) | TDO2IDO1 | |
| SCHEMBL17652000 | 0.88 | TDO2 (0.46) | TDO2IDO1 | |
| SCHEMBL17651995 | 0.88 | TDO2 (0.46) | TDO2IDO1 | |
| SCHEMBL17665351 | 0.87 | TDO2 (0.48) | TDO2IDO1 | |
| SCHEMBL17665353 | 0.86 | TDO2 (0.45) | TDO2IDO1 | |
| SCHEMBL17665686 | 0.81 | TDO2 (0.47) | TDO2IDO1 | |
| SCHEMBL17651986 | 0.79 | TDO2 (0.43) | TDO2IDO1 | |
| SCHEMBL17665680 | 0.79 | TDO2 (0.43) | TDO2IDO1 | |
| SCHEMBL17665689 | 0.77 | TDO2 (0.42) | TDO2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016051181-A1 | 4H-IMIDAZO[1,5-A]INDOLE DERIVATIVES AND THEIR USE AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) AND/OR TRYPTOPHAN 2,3-DIOXYGENASE (TD02) MODULATORS | REDX PHARMA PLC (GB) | 2016-04-07 | — | — | WO | disclosed |