SCHEMBL1766727

SCHEMBL1766727

O=C(Nc1c(I)cc(C(F)(C(F)(F)F)C(F)(F)F)cc1C(F)(F)F)c1cccc(NC(=O)c2ccc(Cl)cc2Br)c1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 4/20 0.49
NR1H4 Q96RI1 4/20 0.49
PPARD Q03181 2/20 0.49
PPARA Q07869 1/20 0.49
RXFP1 Q9HBX9 5/20 0.46
RHOC P08134 1/20 0.46
RHOA P61586 1/20 0.46
TMPRSS4 Q9NRS4 2/20 0.43
PTGES O14684 1/20 0.42
SLC2A1 P11166 1/20 0.42
P2RX1 P51575 1/20 0.42
P2RX4 Q99571 1/20 0.42
P2RX7 Q99572 1/20 0.42
KCNK3 O14649 2/20 0.41
KCNK9 Q9NPC2 2/20 0.41
MAPT P10636 2/20 0.40
CSF1R P07333 1/20 0.40
MEN1 O00255 1/20 0.40
LMNA P02545 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1766995 0.91 PPARG (0.51) PPARGNR1H4PPARDPPARARXFP1
SCHEMBL1766741 0.90 F2R (0.45) PPARGNR1H4PPARDPPARARXFP1
SCHEMBL1766570 0.88 MAPT (0.47) PPARGNR1H4PPARDPPARARXFP1
SCHEMBL1766340 0.85 RXFP1 (0.53) RXFP1PTGESKCNK3KCNK9MAPT
SCHEMBL1766591 0.85 PPARG (0.44) PPARGNR1H4PPARDPPARARXFP1
SCHEMBL29409945 0.84 KCNK3 (0.55) RXFP1RHOCRHOAPTGESP2RX1
SCHEMBL1766911 0.84 KCNK3 (0.55) RXFP1RHOCRHOAPTGESP2RX1
SCHEMBL1766731 0.84 PTGES (0.44) PPARGNR1H4PPARDPPARARXFP1
SCHEMBL1767289 0.83 MEN1 (0.53) RXFP1PTGESKCNK3KCNK9MAPT
SCHEMBL1766845 0.82 MEN1 (0.51) PPARGNR1H4PPARDPPARARXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230226037-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2023-07-20 US disclosed
US-11696913-B2 Prolonged ectoparasite-controlling agent for animal MITSUI CHEMICALS AGRO, INC. (JP) 2023-07-11 US disclosed
US-20200281914-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MITSUI CHEMICALS AGRO, INC. (JP) 2020-09-10 US disclosed
US-10582708-B2 Amide derivative, pest control agent containing the amide derivative, and use of the amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2020-03-10 US disclosed
WO-2019059412-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MITSUI CHEMICALS AGRO, INC. (JP) 2019-03-28 WO disclosed
US-20170367329-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE MITSUI CHEMICALS CROP & LIFE SOLUTIONS, INC. (JP) 2017-12-28 US disclosed
US-9756856-B2 Amide derivative, pest control agent containing the amide derivative, and use of the amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2017-09-12 US disclosed
EP-2319830-B1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE PEST CONTROL AGENT MITSUI CHEMICALS AGRO INC (JP) 2016-11-02 EP disclosed
US-9237745-B2 Amide derivative, pest control agent containing the amide derivative, and use of the amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2016-01-19 US disclosed
US-20130310459-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE MITSUI CHEMICALS AGRO, INC. (JP) 2013-11-21 US disclosed
US-20130231392-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE MITSUI CHEMICALS ARGO, INC. (JP) 2013-09-05 US disclosed
US-20110201687-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE MITSUI CHEMICALS AGRO, INC. (JP) 2011-08-18 US disclosed
EP-2319830-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE AND USE OF THE PEST CONTROL AGENT Mitsui Chemicals Agro, Inc. (JP) 2011-05-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11696913-B2 Prolonged ectoparasite-controlling agent for animal MTX1, ENPP1, CAT PPARG 2878/4885NR1H4 4243/4885PPARD 4191/4885
US-20230226037-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MTX1, ENPP1, CAT PPARG 2878/4885NR1H4 4243/4885PPARD 4191/4885
US-10582708-B2 Amide derivative, pest control agent containing the amide derivative, and use of the amide derivative H1-2, H1-4, H1-0 PPARG 1639/4885NR1H4 3407/4885PPARD 2073/4885
US-20170367329-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE H1-2, H1-4, H1-0 PPARG 1639/4885NR1H4 3407/4885PPARD 2073/4885
US-20130310459-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE H1-2, H1-0, H1-4 PPARG 1904/4885NR1H4 3554/4885PPARD 2700/4885
US-20110201687-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE H1-2, H1-4, H1-0 PPARG 1639/4885NR1H4 3407/4885PPARD 2073/4885
US-20200281914-A1 PROLONGED ECTOPARASITE-CONTROLLING AGENT FOR ANIMAL MTX1, ENPP1, CAT PPARG 2878/4885NR1H4 4243/4885PPARD 4191/4885
US-20130231392-A1 AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE, AND USE OF THE AMIDE DERIVATIVE H1-2, H1-0, H1-4 PPARG 1904/4885NR1H4 3554/4885PPARD 2700/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.