Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 10/20 | 0.59 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.48 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.48 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.48 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.48 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.48 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.48 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.48 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.48 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.48 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.48 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.48 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.48 |
| ▸ | PSMB3 | P49720 | 1/20 | 0.48 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.48 |
| ▸ | PSMA6 | P60900 | 1/20 | 0.48 |
| ▸ | PSMA8 | Q8TAA3 | 1/20 | 0.48 |
| ▸ | PSMB7 | Q99436 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10005122 | 0.89 | PSMB5 (0.47) | GPR139PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL17667670 | 0.87 | GPR139 (0.59) | GPR139PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL17667668 | 0.86 | SLC6A9 (0.52) | GPR139PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL10005167 | 0.86 | PSMB11 (0.49) | GPR139PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL4802883 | 0.83 | PSMB5 (0.69) | GPR139PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL10005139 | 0.83 | PSMB5 (0.59) | GPR139PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL10005021 | 0.83 | PSMB5 (0.71) | GPR139PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL30529994 | 0.83 | PSMB5 (0.71) | GPR139PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL10004915 | 0.82 | PSMB5 (0.55) | GPR139PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL10004622 | 0.82 | PSMB5 (0.58) | GPR139PSMB11PSMA7PSMB1PSMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560647-B1 | COMBINATION THERAPY WITH A PROTEASOME INHIBITOR AND A GALLIUM COMPLEX | NIIKI PHARMA INC (US) | 2016-04-13 | — | — | EP | claimed |