Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 1/20 | 0.80 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17667834 | 0.89 | SMO (0.83) | SMO | |
| Tak-441 SCHEMBL1061476 | 0.89 | SMO (1.00) | SMO | |
| SCHEMBL1062538 | 0.84 | SMO (0.87) | SMO | |
| SCHEMBL1062658 | 0.83 | SMO (0.68) | SMO | |
| SCHEMBL1062967 | 0.82 | SMO (0.87) | SMO | |
| SCHEMBL3428548 | 0.82 | SMO (0.72) | SMO | |
| SCHEMBL1058049 | 0.82 | SMO (0.86) | SMOHPGDS | |
| SCHEMBL13708860 | 0.82 | SMO (0.67) | SMO | |
| SCHEMBL1063022 | 0.81 | SMO (0.68) | SMO | |
| SCHEMBL1063020 | 0.81 | SMO (0.68) | SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247588-B1 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2016-04-13 | — | — | EP | claimed |