Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.75 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.75 |
| ▸ | FLT3 | P36888 | 10/20 | 0.61 |
| ▸ | KIT | P10721 | 9/20 | 0.61 |
| ▸ | FLT1 | P17948 | 7/20 | 0.61 |
| ▸ | LCK | P06239 | 5/20 | 0.61 |
| ▸ | BLK | P51451 | 5/20 | 0.61 |
| ▸ | FLT4 | P35916 | 5/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.61 |
| ▸ | CSNK1G2 | P78368 | 4/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.61 |
| ▸ | CSNK1G1 | Q9HCP0 | 4/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.61 |
| ▸ | CLK2 | P49760 | 3/20 | 0.61 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.61 |
| ▸ | AXL | P30530 | 3/20 | 0.61 |
| ▸ | FRK | P42685 | 3/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.61 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23264574 | 0.87 | KDR (0.74) | KDRPDGFRBFLT3KITFLT1 | |
| SCHEMBL17668154 | 0.86 | KDR (1.00) | KDRPDGFRBFLT3KITFLT1 | |
| SCHEMBL17668142 | 0.85 | KDR (0.81) | KDRPDGFRBFLT3KITFLT1 | |
| SCHEMBL18768789 | 0.85 | KDR (0.71) | KDRPDGFRBFLT3KITFLT1 | |
| SCHEMBL17668141 | 0.85 | KDR (1.00) | KDRPDGFRBFLT3KITFLT1 | |
| SCHEMBL17668227 | 0.82 | KDR (1.00) | KDRPDGFRBFLT3KITFLT1 | |
| SCHEMBL17678674 | 0.82 | KDR (1.00) | KDRPDGFRBFLT3KITFLT1 | |
| SCHEMBL17668229 | 0.82 | KDR (0.76) | KDRPDGFRBFLT3KITFLT1 | |
| SCHEMBL17668243 | 0.81 | KDR (1.00) | KDRPDGFRBFLT3KITFLT1 | |
| SCHEMBL17678675 | 0.80 | KDR (1.00) | KDRPDGFRBFLT3KITFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210115029-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2021-04-22 | — | — | US | disclosed |
| US-10669265-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2020-06-02 | — | — | US | disclosed |
| US-10633373-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2020-04-28 | — | — | US | disclosed |
| US-20180111921-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2018-04-26 | — | — | US | disclosed |
| US-20180105515-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2018-04-19 | — | — | US | disclosed |
| US-9868726-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2018-01-16 | — | — | US | disclosed |
| US-20170107210-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN INC (US) | 2017-04-20 | — | — | US | disclosed |
| US-9371314-B2 | Pyridyl benzothiophenes as kinase inhibitors | ALLERGAN, INC. (US) | 2016-06-21 | — | — | US | disclosed |
| US-20160102080-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | ALLERGAN, INC. | 2016-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102080-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | PDXK, MAP4K5, MAP4K2 | KDR 226/4885PDGFRB 127/4885FLT3 2006/4885 |
| US-20180105515-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | PDXK, MAP4K5, MAP4K2 | KDR 226/4885PDGFRB 127/4885FLT3 2006/4885 |
| US-10633373-B2 | Pyridyl benzothiophenes as kinase inhibitors | PDXK, MAP4K5, MAP4K2 | KDR 226/4885PDGFRB 127/4885FLT3 2006/4885 |
| US-20180111921-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | PDXK, MAP4K5, MAP4K2 | KDR 226/4885PDGFRB 127/4885FLT3 2006/4885 |
| US-20170107210-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | PDXK, MAP4K5, MAP4K2 | KDR 226/4885PDGFRB 127/4885FLT3 2006/4885 |
| US-20210115029-A1 | PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS | PDXK, MAP4K5, MAP4K2 | KDR 226/4885PDGFRB 127/4885FLT3 2006/4885 |
| US-10669265-B2 | Pyridyl benzothiophenes as kinase inhibitors | PDXK, MAP4K5, MAP4K2 | KDR 226/4885PDGFRB 127/4885FLT3 2006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.