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SCHEMBL17668243

SCHEMBL17668243

Cc1ccc(F)c(NC(=O)Nc2ccc(-c3cc(B4OC(C)(C)C(C)(C)O4)cnc3N)cc2)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDR P35968 18/20 1.00
▸ PDGFRB P09619 12/20 1.00
▸ FLT1 P17948 4/20 0.56
▸ FLT3 P36888 6/20 0.56
▸ KIT P10721 5/20 0.56
▸ LCK P06239 3/20 0.54
▸ BLK P51451 3/20 0.54
▸ FLT4 P35916 2/20 0.54
▸ ROCK2 O75116 2/20 0.54
▸ MAP4K4 O95819 2/20 0.54
▸ CLK2 P49760 2/20 0.54
▸ CSNK1G2 P78368 2/20 0.54
▸ ITK Q08881 2/20 0.54
▸ ROCK1 Q13464 2/20 0.54
▸ HIPK2 Q9H2X6 2/20 0.54
▸ CLK4 Q9HAZ1 2/20 0.54
▸ CSNK1G1 Q9HCP0 2/20 0.54
▸ CDK1 P06493 1/20 0.54
▸ AXL P30530 1/20 0.54
▸ FRK P42685 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17668177 0.84 PDGFRB (1.00) KDRPDGFRB
SCHEMBL17668232 0.84 KDR (1.00) KDRPDGFRBFLT1FLT3KIT
SCHEMBL58763 0.82 KDR (0.69) KDRPDGFRBFLT1FLT3KIT
SCHEMBL29375102 0.82 KDR (0.69) KDRPDGFRBFLT1FLT3KIT
SCHEMBL17668136 0.81 KDR (0.75) KDRPDGFRBFLT1FLT3KIT
SCHEMBL23264574 0.80 KDR (0.74) KDRPDGFRBFLT1FLT3KIT
SCHEMBL17668154 0.79 KDR (1.00) KDRPDGFRBFLT1FLT3KIT
SCHEMBL18768789 0.79 KDR (0.71) KDRPDGFRBFLT1FLT3KIT
SCHEMBL17668141 0.79 KDR (1.00) KDRPDGFRBFLT1FLT3KIT
SCHEMBL17668142 0.79 KDR (0.81) KDRPDGFRBFLT1FLT3KIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10669265-B2 Pyridyl benzothiophenes as kinase inhibitors ALLERGAN, INC. (US) 2020-06-02 — — US claimed
US-20180111921-A1 PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS ALLERGAN INC (US) 2018-04-26 — — US claimed
US-20170107210-A1 PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS ALLERGAN INC (US) 2017-04-20 — — US claimed
US-20160102080-A1 PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS ALLERGAN, INC. 2016-04-14 — — US claimed
US-20210115029-A1 PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS ALLERGAN INC (US) 2021-04-22 — — US disclosed
US-20210115029-A1 PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS ALLERGAN INC (US) 2021-04-22 — — US disclosed
US-10669265-B2 Pyridyl benzothiophenes as kinase inhibitors ALLERGAN, INC. (US) 2020-06-02 — — US disclosed
US-10669265-B2 Pyridyl benzothiophenes as kinase inhibitors ALLERGAN, INC. (US) 2020-06-02 — — US disclosed
US-10633373-B2 Pyridyl benzothiophenes as kinase inhibitors ALLERGAN, INC. (US) 2020-04-28 — — US disclosed
US-10633373-B2 Pyridyl benzothiophenes as kinase inhibitors ALLERGAN, INC. (US) 2020-04-28 — — US disclosed
US-20180111921-A1 PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS ALLERGAN INC (US) 2018-04-26 — — US disclosed
US-20180111921-A1 PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS ALLERGAN INC (US) 2018-04-26 — — US disclosed
US-9868726-B2 Pyridyl benzothiophenes as kinase inhibitors ALLERGAN, INC. (US) 2018-01-16 — — US disclosed
US-9868726-B2 Pyridyl benzothiophenes as kinase inhibitors ALLERGAN, INC. (US) 2018-01-16 — — US disclosed
US-20170107210-A1 PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS ALLERGAN INC (US) 2017-04-20 — — US disclosed
US-20170107210-A1 PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS ALLERGAN INC (US) 2017-04-20 — — US disclosed
US-9371314-B2 Pyridyl benzothiophenes as kinase inhibitors ALLERGAN, INC. (US) 2016-06-21 — — US disclosed
US-9371314-B2 Pyridyl benzothiophenes as kinase inhibitors ALLERGAN, INC. (US) 2016-06-21 — — US disclosed
US-20160102080-A1 PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS ALLERGAN, INC. 2016-04-14 — — US disclosed
US-20160102080-A1 PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS ALLERGAN, INC. 2016-04-14 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160102080-A1 PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS PDXK, MAP4K5, MAP4K2 KDR 226/4885PDGFRB 127/4885FLT1 325/4885
US-10633373-B2 Pyridyl benzothiophenes as kinase inhibitors PDXK, MAP4K5, MAP4K2 KDR 226/4885PDGFRB 127/4885FLT1 325/4885
US-20180111921-A1 PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS PDXK, MAP4K5, MAP4K2 KDR 226/4885PDGFRB 127/4885FLT1 325/4885
US-20170107210-A1 PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS PDXK, MAP4K5, MAP4K2 KDR 226/4885PDGFRB 127/4885FLT1 325/4885
US-20210115029-A1 PYRIDYL BENZOTHIOPHENES AS KINASE INHIBITORS PDXK, MAP4K5, MAP4K2 KDR 226/4885PDGFRB 127/4885FLT1 325/4885
US-10669265-B2 Pyridyl benzothiophenes as kinase inhibitors PDXK, MAP4K5, MAP4K2 KDR 226/4885PDGFRB 127/4885FLT1 325/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.