Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CASP6 | P55212 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10767704 | 0.80 | TDP1 (0.39) | TDP1ALDH1A1VCAM1HTTPDE10A | |
| SCHEMBL3200434 | 0.76 | TDP1 (0.38) | TDP1ALDH1A1PDE10APOLBMAPT | |
| SCHEMBL12274556 | 0.72 | CASP6 (0.41) | TDP1ALDH1A1CASP6KDM4ELMNA | |
| SCHEMBL2067226 | 0.72 | ALDH1A1 (0.42) | TDP1ALDH1A1HTTMAPTMEN1 | |
| SCHEMBL29241423 | 0.67 | TDP1 (0.45) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL6401677 | 0.66 | — | — | |
| SCHEMBL407098 | 0.66 | — | — | |
| SCHEMBL2602388 | 0.65 | ALDH1A1 (0.50) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL2075134 | 0.65 | TDP1 (0.45) | TDP1ATMALDH1A1HIF1AVCAM1 | |
| SCHEMBL3200439 | 0.64 | ALDH1A1 (0.34) | TDP1ALDH1A1HTTPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | Genentech, Inc. (US) | 2017-08-16 | — | — | EP | disclosed |
| WO-2016055028-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2016-04-14 | — | — | WO | disclosed |